INT18835

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CASP4) intracellular (CASP4)
Anatomy Link Frequency
granulocytes 2
CASP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 99.22 Very High Very High Very High
Dynorphin 2 98.24 Very High Very High Very High
Enkephalin 4 97.84 Very High Very High Very High
Opioid 6 96.96 Very High Very High Very High
narcan 6 88.08 High High
Inflammation 2 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the opioid peptides tested [(D-Ala2, D-Leu5)-enkephalin (DADL), (D-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAGO) or dynorphin 1-9 (Dyn 1-9)] was capable of mimicking morphine effects, while Dyn 1-9 per se induced TxB2 and LTB4 secretion from granulocytes.
Localization (secretion) of TxB2 in granulocytes associated with dynorphin, enkephalin, opioid and morphine
1) Confidence 0.04 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 1.06
Morphine was found to inhibit human granulocyte aggregation and ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4) secretion during cell aggregation.
Localization (secretion) of TxB2 in granulocyte associated with morphine
2) Confidence 0.03 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 0.96

General Comments

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