INT188350

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.46
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4) kinase activity (Map2k4)
response to stress (Map2k4) cytoplasm (Map2k4)
Anatomy Link Frequency
nucleus 1
Map2k4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 68.28 Quite High
tolerance 1 50.72 Quite High
palliative 3 50.00 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 98.32 Very High Very High Very High
Shock 3 96.56 Very High Very High Very High
Carcinoma 2 91.80 High High
Lymphatic System Cancer 1 89.04 High High
Congenital Anomalies 4 79.48 Quite High
Mucositis 74 50.00 Quite Low
General Immunology 7 50.00 Quite Low
Cancer 17 48.40 Quite Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Stomatitis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCM2, MAP3K3 and the phosphorylated forms of MAP2K3/MAP2K6 and MAP2K4 were also detected throughout preimplantation development.
Localization (forms) of MAP2K4
1) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
Other studies have established that JNK/SAPK and MAP2K4 are activated and translocated into the nucleus in response to cellular stress [29,30].
Localization (translocated) of MAP2K4 in nucleus associated with stress
2) Confidence 0.67 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.19 Pain Relevance 0
These, identified by microarray include, PI3-K, JAK2, JAK3, STAT3, Grb2, IRS, and PLCgamma1, Rho-GTPase activating protein (RAB35), kinases (MEK kinase 1 and 4, PKC, MLCK, cyclin G-associated kinase, EphA1, JNK kinase, MAP kinase 1), phosphatases (meprin, PTPK, protein phosphatase 2 subunit), and heat shock proteins (Hsp60 precursor), as well as SOCS (25).
Localization (cyclin) of JNK kinase associated with shock
3) Confidence 0.13 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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