INT188355

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 8.29
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
T cell 10
CD86 1
immune cells 1
cornea 1
Cd28 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 40 99.92 Very High Very High Very High
Arthritis 167 98.64 Very High Very High Very High
rheumatoid arthritis 347 98.36 Very High Very High Very High
cytokine 220 97.76 Very High Very High Very High
Potency 6 96.88 Very High Very High Very High
abatacept 159 88.20 High High
Inflammation 144 86.84 High High
Infliximab 1 82.04 Quite High
antagonist 19 78.80 Quite High
Lasting pain 1 68.60 Quite High
Disease Link Frequency Relevance Heat
Arthritis 134 98.64 Very High Very High Very High
Infection 97 98.60 Very High Very High Very High
Rheumatoid Arthritis 351 98.36 Very High Very High Very High
Cold Sores 53 98.20 Very High Very High Very High
Shock 1 97.96 Very High Very High Very High
Disease 329 97.20 Very High Very High Very High
Autoimmune Disease 245 96.76 Very High Very High Very High
Immunization 33 94.04 High High
Cancer 69 90.24 High High
Necrosis 35 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore analysed whether the frequencies of CD4+CD28null T cells in the circulation and in the synovial fluid were associated with the presence of ACPA in these compartments.
CD28null Binding (associated) of in T cells
1) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.64 Pain Relevance 0.09
CD28 ligation increases the proliferative response of both CD4+ and CD8+ T cell subsets via these molecular pathways.
CD28 Binding (ligation) of in T cell
2) Confidence 0.32 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.10
We explored some of the cellular mechanisms whereby CD28 engagement inhibited Th17 differentiation.
CD28 Binding (engagement) of
3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.08 Pain Relevance 0.03
However, CD28 ligation during secondary cultures did not suppress but rather significantly enhanced IL-17 production in Th17 differentiated cells.
CD28 Binding (ligation) of
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.09 Pain Relevance 0.08
We here demonstrate in vitro that ligation of CD28 with a monoclonal antibody results in inhibition of Th17 differentiation whereas CTLA4-Ig blockade enhances it during APC/T cell interactions.
CD28 Binding (ligation) of in T cell
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.06 Pain Relevance 0.04
How does this appreciation of CD28-mediated co-stimulation help us to understand the action of CTLA4-Ig treatment in RA?
CD28 Binding (appreciation) of associated with rheumatoid arthritis
6) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.29 Pain Relevance 0.13
CD28 does not stimulate all signaling effectors that are activated by the TCR, but primarily provides a potent synergistic signal for transcription factors such as nuclear factor-?
CD28 Binding (provides) of
7) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.05 Pain Relevance 0
Loss of CD28 occurs normally with age, but this process may be accelerated in susceptible individuals.
CD28 Binding (Loss) of
8) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.46 Pain Relevance 0
In this context it is important to note that anti-CD28 antibodies that bind to the laterally exposed C"D loop of the immunoglobulin-like domain of CD28 - distant from the natural ligand-binding domain - induces NF-?
CD28 Binding (bind) of
9) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0 Pain Relevance 0
Similar to CD28, its cytoplasmic domain has a sequence motif that facilitates the binding of the p85 subunit of PI3-K [60].
CD28 Binding (binding) of
10) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.29 Pain Relevance 0.08
The best way to inhibit CD28-CD80/CD86 interaction is by means of cytotoxic T-lymphocyte antigen (CTLA)4-immunoglobulin (Ig).
CD28 Binding (interaction) of in CD86
11) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.13 Pain Relevance 0.13
Systemic blockade of B7/CD28 costimulatory interactions using fusion protein CTLA4Ig minimizes the immunoinflammatory lesions caused by HSV infection of the cornea [8,9].
CD28 Binding (interactions) of in cornea associated with cold sores and infection
12) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.84 Pain Relevance 0
In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.
CD28 Binding (interaction) of in T cell
13) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.99 Pain Relevance 0.49
mAbs restored IL-17 production and thus completely abrogated the effect of CD28 engagement (Fig. 4B).
CD28 Binding (engagement) of
14) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.18 Pain Relevance 0.04
CD28 ligation of naïve T cells has been proven to be essential for IL-2 production and cell proliferation [36].
CD28 Binding (ligation) of in T cells
15) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.07 Pain Relevance 0.04
mAbs abrogated the effect of CD28 engagement.
CD28 Binding (engagement) of
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.12 Pain Relevance 0.08
Nonetheless, since CD28 engagement alters the Th17/Th1 ratio toward Th1, under some circumstances it may aggravate autoimmunity [37], [38].
CD28 Binding (engagement) of associated with autoimmune disease
17) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.34 Pain Relevance 0.12
We showed that CD28 engagement strongly inhibited naïve T cell differentiation into Th17 without preventing their proliferation (Fig. 2A).
CD28 Binding (engagement) of in T cell
18) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0.06
We next verified whether CD28 engagement further regulates T cells that have been differentiated into Th17 with anti-CD3 in the absence of co-stimulation.
CD28 Spec (whether) Binding (engagement) of in T cells
19) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that the B7 family of proteins, which interact with CD28 signaling proteins on the surface of immune cells, are important regulators of the immune response.
CD28 Binding (interact) of in immune cells
20) Confidence 0.20 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2760136 Disease Relevance 1.06 Pain Relevance 0.45

General Comments

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