INT18836

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Context Info
Confidence 0.38
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADRA2A) small molecule metabolic process (ADRA2A) plasma membrane (ADRA2A)
cytoplasm (ADRA2A) signal transducer activity (ADRA2A)
Anatomy Link Frequency
plasma 1
cerebral cortex 1
ADRA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 98.24 Very High Very High Very High
cerebral cortex 4 97.76 Very High Very High Very High
noradrenaline 5 92.72 High High
agonist 6 89.04 High High
Clonidine 1 86.88 High High
Analgesic 1 48.36 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 75.00 Quite High
Disease 1 69.16 Quite High
Cancer 1 50.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that release-inhibiting adrenoceptors of the alpha 2-subtype exist on 5-hydroxytryptamine terminals innervating the cerebral cortex in human and guinea-pig brain.
Localization (release-inhibiting) of alpha 2-subtype in cerebral cortex associated with cerebral cortex
1) Confidence 0.38 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1982558 Disease Relevance 0.05 Pain Relevance 0.64
Confocal laser microscopy showed that APLP1 causes a considerable shift of the alpha2A-adrenergic receptor localization from plasma membrane to intracellular compartments.
Localization (localization) of alpha2A-adrenergic in plasma
2) Confidence 0.16 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.28 Pain Relevance 0.11

General Comments

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