INT188376

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.29
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
macrophages 3
colon 2
fibroblast 2
endothelial cells 1
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 16 99.80 Very High Very High Very High
Inflammation 61 97.80 Very High Very High Very High
Arthritis 108 93.12 High High
rheumatoid arthritis 58 82.48 Quite High
psoriasis 7 81.20 Quite High
cva 2 63.84 Quite High
corticosteroid 12 33.44 Quite Low
Potency 3 29.36 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 95 99.40 Very High Very High Very High
Atherosclerosis 1 99.04 Very High Very High Very High
Colon Cancer 6 98.16 Very High Very High Very High
INFLAMMATION 60 97.80 Very High Very High Very High
Hyperplasia 5 97.12 Very High Very High Very High
Arthritis 112 93.12 High High
Colorectal Cancer 18 92.92 High High
Appetite Loss 24 88.64 High High
Rheumatoid Arthritis 58 82.48 Quite High
Apoptosis 28 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, TM can inhibit the expression of vascular endothelial growth factor in serum synovial tissues, especially in endothelial cells and macrophages.
Negative_regulation (inhibit) of Gene_expression (expression) of vascular endothelial growth factor in macrophages
1) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297562 Disease Relevance 1.64 Pain Relevance 0.51
G. glabra decreases vascular endothelial growth factor production and cytokine-induced neovascularization [10].
Negative_regulation (decreases) of Gene_expression (production) of vascular endothelial growth factor associated with cytokine
2) Confidence 0.13 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2993704 Disease Relevance 0.43 Pain Relevance 0.08
Down-regulation of endothelial growth factor expression and thus inhibition of angiogenesis in human colon cancer can be achieved with wild type p53 gene transfer (23).
Negative_regulation (regulation) of Gene_expression (expression) of endothelial growth factor in colon associated with colon cancer
3) Confidence 0.11 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.29 Pain Relevance 0
Interestingly, TM can inhibit the expression of vascular endothelial growth factor in serum synovial tissues, especially in endothelial cells and macrophages.
Negative_regulation (inhibit) of in endothelial cells Gene_expression (expression) of vascular endothelial growth factor in macrophages
4) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297562 Disease Relevance 1.64 Pain Relevance 0.51
Calcineurin inhibitors also block lymphokine production and release, fibroblast proliferation, and vascular endothelial growth factor expression (Dumont 1996; Ho et al 1996; Cho et al 2002).
Negative_regulation (block) of Gene_expression (expression) of vascular endothelial growth factor in fibroblast
5) Confidence 0.09 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699819 Disease Relevance 0.28 Pain Relevance 0.09

General Comments

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