INT188391

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, HLA-DRB1) endosome (HLA-DRB1) signal transduction (CD4)
Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1) cell adhesion (CD4)
Anatomy Link Frequency
telomere 1
CD4 (Homo sapiens)
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 89.80 High High
rheumatoid arthritis 81 88.20 High High
Multiple sclerosis 1 51.36 Quite High
Inflammation 3 45.16 Quite Low
metalloproteinase 1 12.32 Low Low
methotrexate 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Leflunomide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 32 100.00 Very High Very High Very High
Necrosis 2 90.76 High High
Cancer 2 90.40 High High
Rheumatoid Arthritis 81 88.20 High High
Communicable Diseases 1 62.92 Quite High
Demyelinating Disease 1 51.36 Quite High
Diabetes Mellitus 1 50.56 Quite High
Autoimmune Disease 2 49.16 Quite Low
INFLAMMATION 3 45.16 Quite Low
Disorder Of Lipid Metabolism 4 39.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD4+ T cells, in contrast, have initially been implied in the pathogenesis of the disease because of the association of related HLA DRB1 alleles with susceptibility to and severity of the disease, and have subsequently been found to exhibit numerous pathological features such as oligoclonal expansions, contraction of T cell receptor repertoire, shortened telomere fragments indicative of increased replicative history, and distinct pathological phenotypes [15-19].
CD4 Binding (association) of HLA DRB1 in telomere associated with disease
1) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.96 Pain Relevance 0.34

General Comments

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