INT188396

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.78
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
anterior region 6
liver 2
peritoneum 2
monocyte 2
posterior 2
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 28 99.52 Very High Very High Very High
Versed 1 88.28 High High
imagery 55 86.36 High High
dexamethasone 65 84.80 Quite High
Inflammatory stimuli 2 79.20 Quite High
rheumatoid arthritis 163 76.48 Quite High
cytokine 65 72.16 Quite High
Inflammation 21 71.80 Quite High
intrathecal 84 50.00 Quite Low
Paracetamol 3 34.36 Quite Low
Disease Link Frequency Relevance Heat
Liver Disease 2 99.20 Very High Very High Very High
Coronary Stenosis 20 99.16 Very High Very High Very High
Renal Failure 4 98.66 Very High Very High Very High
Myocardial Infarction 15 96.98 Very High Very High Very High
Pathologic Constriction 78 95.08 Very High Very High Very High
Polycystic Kidney Disease 62 83.60 Quite High
INFLAMMATION 25 78.88 Quite High
Rheumatoid Arthritis 163 76.48 Quite High
Cyst 32 70.16 Quite High
Disease 119 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the significant changes in lidocaine pharmacokinetics in cardiac failure, no significant changes in lidocaine pharmacokinetics are observed in renal failure; whereas, in liver disease, only lidocaine clearance is impaired, leading in turn to an increased half life (Fig. 1g).


Positive_regulation (leading) of Positive_regulation (increased) of Fig in liver associated with liver disease, renal failure, lidocaine and myocardial infarction
1) Confidence 0.42 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005109 Disease Relevance 0.64 Pain Relevance 0.54
Fig5Autoregulation resistances in the absence of a coronary stenosis of the myocardial layers as a function of DTF

Comparison of endocardial and epicardial flow

Positive_regulation (resistances) of Positive_regulation (5Autoregulation) of Fig associated with coronary stenosis
2) Confidence 0.36 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441532 Disease Relevance 0.42 Pain Relevance 0
The relative risk of coronary events increased with increasing CAC burden (Fig. 1).
Positive_regulation (increased) of Positive_regulation (increasing) of Fig
3) Confidence 0.20 Published 2008 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2493606 Disease Relevance 0.06 Pain Relevance 0.17
, indicating that cell-contact-dependent stimuli were necessary for monocyte activation (Fig. 1b).
Positive_regulation (necessary) of Positive_regulation (activation) of Fig in monocyte
4) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.20 Pain Relevance 0.07
production in those experiments (data not shown), and induced only a modest but not statistically significant increase in a later set of co-culture experiments (Fig. 1b).
Positive_regulation (induced) of Neg (not) Positive_regulation (increase) of Fig
5) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0 Pain Relevance 0.03
However the rate of increase between the first and second week of culture was far greater for collagen accumulation than for cell number with a 100% increase in the amount of collagen compared with about 25% increase in cell number in the control cultures suggesting a process of differentiation and specific increase in collagen accumulation (Fig. 3A).
Positive_regulation (increase) of Positive_regulation (accumulation) of Fig
6) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.29
The effect of steady streaming resulting from an oscillating flow field on the given geometry is illustrated in Fig. 3.Fig. 3Simulation of drug transport starting at T11 (a) and propagating caudal in the lateral and cranial in the posterior and anterior region for five (b) and 10 s (c) using a steady streaming vector field previously determined by an oscillating fluid flow simulation (scaled to 50% of the initial concentration)

Simulating CSF motion

Positive_regulation (illustrated) of Positive_regulation (3Simulation) of Fig in anterior region
7) Confidence 0.10 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0
The effect of steady streaming resulting from an oscillating flow field on the given geometry is illustrated in Fig. 3.Fig3Simulation of drug transport starting at T11 (a) and propagating caudal in the lateral and cranial in the posterior and anterior region for five (b) and 10 s (c) using a steady streaming vector field previously determined by an oscillating fluid flow simulation (scaled to 50% of the initial concentration)

Simulating CSF motion

Positive_regulation (illustrated) of Positive_regulation (3Simulation) of Fig in anterior region
8) Confidence 0.10 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0
When the peritoneum and the mesenterial fatty tissue were opened, the fluorescent spots became even more bright (Fig. 3), and the lymph nodes then also could be identified by normal light.Fig1View obtained during experiment 3 at 12 min after injectionFig. 2View obtained during experiment 3 at 15 min after injectionFig. 3View obtained during experiment 3 at 20 min after injection
Positive_regulation (normal) of Positive_regulation (1View) of Fig in peritoneum
9) Confidence 0.07 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2939337 Disease Relevance 0 Pain Relevance 0
Activation of P2X7R by the nucleotide leads to the assembly of a multi-protein complex called the NLRP3 inflammasome that recruits pro-caspase-1 and induces its proteolytic activation (Fig. 3) [53–55].
Positive_regulation (induces) of Positive_regulation (activation) of Fig
10) Confidence 0.05 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.15 Pain Relevance 0.11
The translocation of Id2 in cells with mutated polycystins is associated with downregulation of p21 expression, leading to an increase in CDK2 activity and cell cycle progression (Fig. 3).
Positive_regulation (leading) of Positive_regulation (increase) of Fig
11) Confidence 0.04 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.32 Pain Relevance 0
The effect of steady streaming resulting from an oscillating flow field on the given geometry is illustrated in Fig. 3.Fig. 3Simulation of drug transport starting at T11 (a) and propagating caudal in the lateral and cranial in the posterior and anterior region for five (b) and 10 s (c) using a steady streaming vector field previously determined by an oscillating fluid flow simulation (scaled to 50% of the initial concentration)

Simulating CSF motion

Positive_regulation (illustrated) of in posterior Positive_regulation (3Simulation) of Fig in anterior region
12) Confidence 0.04 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0
The effect of steady streaming resulting from an oscillating flow field on the given geometry is illustrated in Fig. 3.Fig3Simulation of drug transport starting at T11 (a) and propagating caudal in the lateral and cranial in the posterior and anterior region for five (b) and 10 s (c) using a steady streaming vector field previously determined by an oscillating fluid flow simulation (scaled to 50% of the initial concentration)

Simulating CSF motion

Positive_regulation (illustrated) of in posterior Positive_regulation (3Simulation) of Fig in anterior region
13) Confidence 0.04 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0

General Comments

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