INT188397

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.34
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
macrophages 2
neutrophils 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 206 99.30 Very High Very High Very High
rheumatoid arthritis 81 95.92 Very High Very High Very High
cytokine 39 93.92 High High
narcan 10 86.56 High High
antagonist 13 85.44 High High
agonist 23 62.64 Quite High
opioid receptor 42 5.00 Very Low Very Low Very Low
Inflammation 41 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 148 96.48 Very High Very High Very High
Rheumatoid Arthritis 81 95.92 Very High Very High Very High
Disease 47 72.12 Quite High
Death 4 49.04 Quite Low
INFLAMMATION 48 5.00 Very Low Very Low Very Low
Infection 23 5.00 Very Low Very Low Very Low
Systemic Inflammatory Response Syndrome 8 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Critical Illness 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the present results demonstrate that human neutrophils secrete morphine via a Ca2+-dependent mechanism in response to LPS or IL-8 stimulation.


Regulation (response) of Positive_regulation (stimulation) of LPS in neutrophils associated with morphine
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0 Pain Relevance 0.91
response, no difference in LPS-induced TNF-?
Neg (no) Regulation (difference) of Positive_regulation (induced) of LPS
2) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.89 Pain Relevance 0.46
release, we investigated whether prolonged LPS stimulation without P2X7 receptor secondary stimulation could also result in IL-1?
Regulation (prolonged) of Positive_regulation (stimulation) of LPS
3) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.10
Of note, miR-155 and miR-125b, the former upregulated, while the latter down-regulated by LPS stimulation of Raw 264.7 mouse macrophages [13], were not statistically significant dysregulated in the analyzed set of patients.
Regulation (regulated) of Positive_regulation (stimulation) of LPS in macrophages
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.45 Pain Relevance 0

General Comments

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