INT188398

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.64
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IL15) aging (IL15) Golgi apparatus (IL15)
cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)
Anatomy Link Frequency
T cell 2
intestinal epithelium 1
NK cells 1
apoptotic cell 1
IL15 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 4 98.80 Very High Very High Very High
cytokine 233 98.00 Very High Very High Very High
rheumatoid arthritis 81 96.04 Very High Very High Very High
Inflammation 183 88.84 High High
tolerance 16 68.28 Quite High
metalloproteinase 1 61.84 Quite High
chemokine 27 49.92 Quite Low
Multiple sclerosis 2 21.76 Low Low
adenocard 4 12.04 Low Low
corticosteroid 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 99.98 Very High Very High Very High
Asthma 315 99.52 Very High Very High Very High
Disease 144 98.58 Very High Very High Very High
Apoptosis 56 97.48 Very High Very High Very High
Death 16 96.64 Very High Very High Very High
Rheumatoid Arthritis 81 96.04 Very High Very High Very High
Infection 68 93.68 High High
Hepatitis C Virus Infection 126 93.28 High High
Leukemia 14 92.72 High High
INFLAMMATION 201 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is feasible that manipulative forces and intervention-related stress increased the systemic levels of IL-15 in both SMT-C and SMT-NC groups.
Positive_regulation (increased) of IL-15 associated with stress
1) Confidence 0.19 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.24 Pain Relevance 0.03
In the present study, it is not known if any of the procedures (including the "laying on of the hands", the manipulative thrust) to which participants were subjected to, were sufficiently stressful to cause an increase in the systemic output of IL-15.
Positive_regulation (increase) of IL-15
2) Confidence 0.19 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.17 Pain Relevance 0.04
The traditionally described paucity of cytokines of T cell origin in the RA synovial membrane, which has been considered an argument against the involvement of T cells in the pathogenesis of the disease, has been put into perspective by the more recent recognition of high levels of IL-15 [20], IL-17 and, although at low levels, IFN-?
Positive_regulation (levels) of IL-15 in T cells associated with rheumatoid arthritis, disease and cytokine
3) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.75 Pain Relevance 0.37
STAT6 is also constitutively activated in NK2 clones from asthmatic patients possibly as a result of IL-15 stimulating their proliferation [238].
Positive_regulation (result) of IL-15 associated with asthma
4) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.45 Pain Relevance 0.14
The immunosuppressive activity of sirolimus activity is primarily related to blockade of IL-2 and IL-15 induction of B and T cell proliferation via inhibition of p70S6 kinase through high affinity binding to FKBP and prevents progression of the cell cycle from the G1 to S phase.
Positive_regulation (induction) of IL-15 in T cell
5) Confidence 0.06 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.06 Pain Relevance 0
The in vivo relevance of these effects is underscored by the presence of upregulated IL-15 [146,150,151], increased MIC expression on enterocytes [145,149], and CD94+ IEL infiltration [147] in the intestinal epithelium of active celiac patients.
Positive_regulation (upregulated) of IL-15 in intestinal epithelium
6) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.37 Pain Relevance 0
by NK cells in response to IL-12 and IL-15 activation [34].
Positive_regulation (activation) of IL-15 in NK cells
7) Confidence 0.03 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.63 Pain Relevance 0.19
Lymphocytes require IL-2, IL-4, IL-7, IL-9 and IL-15 for viability [252,253], and withdrawal of these cytokines leads to apoptotic cell death.
Positive_regulation (require) of IL-15 in apoptotic cell associated with apoptosis, withdrawal, death and cytokine
8) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 0.96 Pain Relevance 0.29

General Comments

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