INT188403

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.47
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
T cells 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 44 98.76 Very High Very High Very High
Arthritis 2 98.16 Very High Very High Very High
rheumatoid arthritis 72 95.92 Very High Very High Very High
Osteoarthritis 1 80.96 Quite High
cytokine 16 35.04 Quite Low
chemokine 4 34.24 Quite Low
withdrawal 3 15.92 Low Low
Central nervous system 7 8.40 Low Low
Pain 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 92 99.60 Very High Very High Very High
INFLAMMATION 41 98.76 Very High Very High Very High
Arthritis 7 98.16 Very High Very High Very High
Cold Sores 18 98.12 Very High Very High Very High
Infection 28 97.76 Very High Very High Very High
Farber Lipogranulomatosis 41 97.04 Very High Very High Very High
Rheumatoid Arthritis 72 95.92 Very High Very High Very High
Death 44 94.80 High High
Frailty 3 80.96 Quite High
Malignant Neoplastic Disease 4 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (requires) of Positive_regulation (activation) of Fas in T cells associated with death
1) Confidence 0.46 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.33 Pain Relevance 0
Current reports indicate that a medically induced upregulation of the Fas-mediated apoptosis pathway in inflammatory synoviocytes may provide a novel therapeutic strategy for RA treatment [5,12-18].
Positive_regulation (induced) of Positive_regulation (upregulation) of Fas associated with inflammation, rheumatoid arthritis and apoptosis
2) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.57 Pain Relevance 0.34
It may therefore be speculated that increased CD95 signalling mediated by elevated ceramide levels is involved in the inflammatory arthritis of FD.


Positive_regulation (mediated) of Positive_regulation (increased) of CD95 associated with farber lipogranulomatosis, inflammation and arthritis
3) Confidence 0.03 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1920510 Disease Relevance 1.57 Pain Relevance 0.29

General Comments

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