INT188404

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 5.22
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
joints 2
synovium 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 143 99.60 Very High Very High Very High
Inflammation 74 99.16 Very High Very High Very High
Arthritis 2 97.72 Very High Very High Very High
cytokine 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 11 99.84 Very High Very High Very High
Rheumatoid Arthritis 143 99.60 Very High Very High Very High
INFLAMMATION 72 99.16 Very High Very High Very High
Farber Lipogranulomatosis 41 96.08 Very High Very High Very High
Death 18 95.88 Very High Very High Very High
Apoptosis 101 95.60 Very High Very High Very High
Severe Combined Immunodeficiency 70 84.20 Quite High
Malignant Neoplastic Disease 2 63.92 Quite High
Disease 20 61.28 Quite High
Lysosome Storage Disease 4 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here the effect of continuous activation of Fas/FasL interaction through a repeated FasL gene transfer was explored to determine if this treatment could result in the death of inflammatory synoviocytes in RA synovium and elimination of RA tissue in vivo.
Positive_regulation (activation) of Fas Binding (interaction) of in synovium associated with inflammation, rheumatoid arthritis and death
1) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.84 Pain Relevance 0.55
Upregulation of Fas/FasL interaction in arthritic joints by virus vector mediated FasL gene transfer or anti-Fas antibody treatment intra-articularly can induce apoptosis in inflammatory synoviocytes, as has been identified by many groups [5,12-18].
Positive_regulation (Upregulation) of Fas Binding (interaction) of in joints associated with inflammation, apoptosis and arthritis
2) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.83 Pain Relevance 0.53
Indeed, increased CD95 receptor/ligand interaction has been implicated in the pathogenesis of inflammatory arthritis [10,11].
Positive_regulation (increased) of CD95 Binding (interaction) of associated with inflammation and arthritis
3) Confidence 0.03 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1920510 Disease Relevance 1.55 Pain Relevance 0.28

General Comments

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