INT188405

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Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.54
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
cleavage 2
lung 2
T cell 2
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 80 99.20 Very High Very High Very High
rheumatoid arthritis 72 81.84 Quite High
cytokine 23 74.60 Quite High
metalloproteinase 18 70.32 Quite High
agonist 14 66.68 Quite High
ketamine 1 44.96 Quite Low
Inflammatory response 4 26.20 Quite Low
chemokine 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pleurisy 16 99.96 Very High Very High Very High
INFLAMMATION 81 99.20 Very High Very High Very High
Death 45 97.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 3 96.48 Very High Very High Very High
Apoptosis 117 95.36 Very High Very High Very High
Infection 28 84.96 Quite High
Rheumatoid Arthritis 72 81.84 Quite High
Severe Combined Immunodeficiency 35 77.76 Quite High
Stress 2 76.72 Quite High
Disease 17 73.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FasL and Fas have been implicated because activation-induced cell death (AICD), an in vitro model in which mitogen-activated T cell blasts are killed by TCR restimulation, which causes FasL upregulation, is inhibited by FasL or Fas inactivation (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Positive_regulation (causes) of Positive_regulation (upregulation) of FasL in T cell associated with death
1) Confidence 0.64 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.84 Pain Relevance 0.04
The transducibility of Ad-LacZ and Ad-FasL was evaluated by detection of ?
Positive_regulation (evaluated) of Positive_regulation (transducibility) of FasL
2) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.46 Pain Relevance 0.04
We confirm here that the inflammatory process (carrageenan-induced pleurisy) leads to a substantial activation of FasL in the lung tissues which likely contribute in different capacities to the evolution of acute inflammation.
Positive_regulation (leads) of Positive_regulation (activation) of FasL in lung associated with inflammation and pleurisy
3) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.00 Pain Relevance 0.22
Subsequent experiments indicated that TCAH induced a mediated cleavage of FasL rather than suppressing FasL at the level of gene transcription [98].
Positive_regulation (mediated) of Positive_regulation (cleavage) of FasL in cleavage
4) Confidence 0.31 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.23 Pain Relevance 0.18

General Comments

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