INT188406

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 24.67
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
T lymphocyte 3
spinal cord 2
epithelial cells 1
joints 1
blood 1
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 243 99.68 Very High Very High Very High
cytokine 226 98.84 Very High Very High Very High
rheumatoid arthritis 196 98.48 Very High Very High Very High
Inflammation 190 98.36 Very High Very High Very High
Arthritis 108 85.16 High High
Demyelination 6 75.12 Quite High
Central nervous system 29 70.48 Quite High
anesthesia 11 64.80 Quite High
Inflammatory response 18 57.32 Quite High
agonist 1 53.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 71 100.00 Very High Very High Very High
Necrosis 37 100.00 Very High Very High Very High
Arthritis 120 99.84 Very High Very High Very High
Apoptosis 879 99.70 Very High Very High Very High
Death 197 99.40 Very High Very High Very High
Lymphatic System Cancer 404 99.04 Very High Very High Very High
Infection 182 99.04 Very High Very High Very High
Rheumatoid Arthritis 196 98.48 Very High Very High Very High
INFLAMMATION 210 98.36 Very High Very High Very High
Injury 107 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were incubated in medium alone (no treatment, i.e., cytokine deprivation) or treated with FLAG-tagged human recombinant FasL 10 ng/mL (Alexis) crosslinked with 1 ?
FasL Binding (crosslinked) of associated with cytokine
1) Confidence 0.44 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.37 Pain Relevance 0.11
Strategies to inhibit Fas–FasL interaction may be useful neuroprotective approaches for reducing apoptosis after SCI.
FasL Binding (interaction) of associated with spinal cord injury and apoptosis
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.32 Pain Relevance 0.10
Apoptosis of lymphoma T cells induced by bacterial Sags involves Fas-Fas-L interaction
Fas-L Binding (interaction) of in T cells associated with lymphatic system cancer and apoptosis
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.82 Pain Relevance 0
Other studies, however, have shown that Fas/Fas-L interaction is involved in bacterial Sag mediated apoptosis [36], [42]–[43].
Fas-L Binding (interaction) of associated with apoptosis
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.18 Pain Relevance 0
Upregulation of Fas/FasL interaction in arthritic joints by virus vector mediated FasL gene transfer or anti-Fas antibody treatment intra-articularly can induce apoptosis in inflammatory synoviocytes, as has been identified by many groups [5,12-18].
FasL Binding (interaction) of in joints associated with inflammation, apoptosis and arthritis
5) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.82 Pain Relevance 0.53
Here the effect of continuous activation of Fas/FasL interaction through a repeated FasL gene transfer was explored to determine if this treatment could result in the death of inflammatory synoviocytes in RA synovium and elimination of RA tissue in vivo.
FasL Binding (interaction) of in synovium associated with inflammation, rheumatoid arthritis and death
6) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.82 Pain Relevance 0.55
Blockade of FasL interaction partially increases CD4+ T lymphocyte recovery, in vitro and in vivo [51].
FasL Binding (interaction) of in T lymphocyte
7) Confidence 0.31 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.84 Pain Relevance 0.08
To investigate the induction of apoptotic pathways triggered by Fas-FasL binding, immunohistological staining for FasL in the spinal cord was also determined 24 h after injury.
FasL Binding (binding) of in spinal cord associated with injury, apoptosis and spinal cord
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.28 Pain Relevance 0.42
To investigate the induction of apoptotic pathways triggered by Fas-FasL binding, immunohistological staining for FasL in the spinal cord was also determined 24 h after injury.
FasL Binding (binding) of in spinal cord associated with injury, apoptosis and spinal cord
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.29 Pain Relevance 0.43
Finally, mouse Fas-Fc protein was used as a competitive inhibitor of Fas/Fas-L interactions [36].
Fas-L Binding (interactions) of
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.70 Pain Relevance 0
Mouse Fas-Fc- a competitive inhibitor of Fas-Fas-L interactions effectively inhibited apoptosis in the lymphomas studied confirming the involvement of the Fas-Fas-L pathway in apoptosis induced by bacterial Sags.
Fas-L Binding (interactions) of in Mouse associated with lymphatic system cancer and apoptosis
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.11 Pain Relevance 0
The T-cell apoptosis induced by Fas/FasL binding serves to down-regulate the immune response to antigens.
FasL Binding (binding) of in T-cell associated with apoptosis
12) Confidence 0.27 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.45 Pain Relevance 0.13
The Fas/(FasL) system has been recognized as a major pathway for the induction of apoptosis in cells and tissues.
FasL Binding (recognized) of associated with apoptosis
13) Confidence 0.20 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.42 Pain Relevance 0.14
Analysis of the tissue following treatment demonstrated that synoviocytes and mononuclear cells present in the tissue had been eliminated by apoptosis through a Fas/FasL interaction [106].
FasL Binding (interaction) of in mononuclear cells associated with apoptosis
14) Confidence 0.18 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.37 Pain Relevance 0.36
This usually results in apoptosis via the mitochondrial pathway whereas extrinsic stimuli are molecules such as the Fas Ligand (FasL) and Tumor Necrosis Factor (TNF) which bind to their respective receptors and initiate apoptosis via the death receptor pathway.
FasL Binding (bind) of associated with necrosis, cancer, apoptosis and death
15) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 2.08 Pain Relevance 0.04
This usually results in apoptosis via the mitochondrial pathway whereas extrinsic stimuli are molecules such as the Fas Ligand (FasL) and Tumor Necrosis Factor (TNF) which bind to their respective receptors and initiate apoptosis via the death receptor pathway.
Fas Ligand Binding (bind) of associated with necrosis, cancer, apoptosis and death
16) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 2.08 Pain Relevance 0.04
Nevertheless, one study showed that sera of SJS/TEN were able to induce abundant keratinocyte apoptosis and furthermore that peripheral blood monuclear cells of patients stimulated by the causative drug excreted high levels of sFasL [50], but it should be noted that sera can contain small membrane vesicles with membarne bound FasL that can account for the observed activity.
FasL Binding (bound) of in blood associated with staphylococcus infection, apoptosis and bullous skin disease
17) Confidence 0.16 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.70 Pain Relevance 0.03
[77] and Fas/FasL interactions contribute to death of gastric epithelial cells [78].
FasL Binding (interactions) of in epithelial cells associated with death
18) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.75 Pain Relevance 0.12
When FasR binds its ligand, namely Fas ligand (FasL), a cascade of events follows, including caspase activation, ultimately eventuating in cellular death.
FasL Binding (binds) of associated with death
19) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503670 Disease Relevance 1.24 Pain Relevance 0.08

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