INT188407

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.67
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
joints 2
synovium 2
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 142 99.28 Very High Very High Very High
Inflammation 60 99.16 Very High Very High Very High
cytokine 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 8 99.84 Very High Very High Very High
Rheumatoid Arthritis 142 99.28 Very High Very High Very High
INFLAMMATION 62 99.16 Very High Very High Very High
Death 12 95.88 Very High Very High Very High
Apoptosis 92 95.60 Very High Very High Very High
Severe Combined Immunodeficiency 70 84.20 Quite High
Targeted Disruption 10 22.80 Low Low
Infection 8 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here the effect of continuous activation of Fas/FasL interaction through a repeated FasL gene transfer was explored to determine if this treatment could result in the death of inflammatory synoviocytes in RA synovium and elimination of RA tissue in vivo.
Positive_regulation (activation) of FasL Binding (interaction) of in synovium associated with inflammation, rheumatoid arthritis and death
1) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.84 Pain Relevance 0.55
Upregulation of Fas/FasL interaction in arthritic joints by virus vector mediated FasL gene transfer or anti-Fas antibody treatment intra-articularly can induce apoptosis in inflammatory synoviocytes, as has been identified by many groups [5,12-18].
Positive_regulation (Upregulation) of FasL Binding (interaction) of in joints associated with inflammation, apoptosis and arthritis
2) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.83 Pain Relevance 0.53

General Comments

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