INT188422

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 8.91
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pdxk)
Anatomy Link Frequency
muscle 1
Pdxk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 570 99.68 Very High Very High Very High
Arthritis 350 99.12 Very High Very High Very High
Inflammatory response 10 98.00 Very High Very High Very High
rheumatoid arthritis 230 94.32 High High
Pain 20 91.48 High High
Inflammatory marker 30 86.24 High High
methotrexate 20 5.00 Very Low Very Low Very Low
anesthesia 20 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 230 99.84 Very High Very High Very High
INFLAMMATION 610 99.68 Very High Very High Very High
Coronary Artery Disease 10 98.68 Very High Very High Very High
Injury 10 97.76 Very High Very High Very High
Thrombosis 10 96.48 Very High Very High Very High
Rheumatoid Arthritis 240 94.32 High High
Arthritis 200 91.60 High High
Pain 20 91.48 High High
Inflammatory Bowel Disease 10 91.28 High High
Disease 60 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammation causes tissue-specific depletion of vitamin B6

Previously we observed strong and consistent associations between vitamin B6 status and several indicators of inflammation in patients with rheumatoid arthritis.

Negative_regulation (depletion) of vitamin B6 associated with inflammation and rheumatoid arthritis
1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1297572 Disease Relevance 0.76 Pain Relevance 0.43
Inflammation induced a tissue-specific depletion of vitamin B6.
Negative_regulation (depletion) of vitamin B6 associated with inflammation
2) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297572 Disease Relevance 0.87 Pain Relevance 0.44
Furthermore, the low vitamin B6 level is unlikely to be due to a decrease in food intake or the excessive excretion of vitamin B6.
Negative_regulation (decrease) of vitamin B6
3) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297572 Disease Relevance 0.77 Pain Relevance 0.27
Such strong associations imply that impaired vitamin B6 status in these patients results from inflammation.
Negative_regulation (impaired) of vitamin B6 associated with inflammation
4) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297572 Disease Relevance 0.66 Pain Relevance 0.38
In rats with adjuvant arthritis, hepatic pyridoxal 5'-phosphate content was decreased, whereas muscle pyridoxal 5'-phosphate content remained unaltered, suggesting localized vitamin B6 deficiency during inflammation.
Negative_regulation (deficiency) of vitamin B6 in muscle associated with inflammation, experimental arthritis and arthritis
5) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297572 Disease Relevance 0.75 Pain Relevance 0.38
These observations have attracted attention partly because vitamin B6 deficiency and several markers of inflammation were both found to be independent risk factors for thrombosis [6,7].
Negative_regulation (deficiency) of vitamin B6 associated with inflammation and thrombosis
6) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297572 Disease Relevance 1.09 Pain Relevance 0.28
Decreased vitamin B6 status was also reported in patients after surgery and trauma [12].
Negative_regulation (Decreased) of vitamin B6 associated with injury
7) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297572 Disease Relevance 1.65 Pain Relevance 0.52
Data from our animal model imply localized vitamin B6 depletion during inflammation.
Negative_regulation (depletion) of vitamin B6 associated with inflammation
8) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297572 Disease Relevance 0.80 Pain Relevance 0.40
Possible causes of decreased levels of vitamin B6 are discussed.



Negative_regulation (decreased) of vitamin B6
9) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297572 Disease Relevance 0.71 Pain Relevance 0.35
Furthermore, the low vitamin B6 level is unlikely to be due to a decrease in food intake or the excessive excretion of vitamin B6.
Negative_regulation (decrease) of vitamin B6
10) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297572 Disease Relevance 0.84 Pain Relevance 0.30

General Comments

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