INT18843

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 5.44
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle 1
eosinophil 1
neutrophil 1
H1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 5 100.00 Very High Very High Very High
antagonist 10 99.68 Very High Very High Very High
lidocaine 6 99.62 Very High Very High Very High
headache 1 98.16 Very High Very High Very High
pruritus 1 97.60 Very High Very High Very High
halothane 5 95.04 Very High Very High Very High
Morphine 9 94.20 High High
anesthesia 8 93.92 High High
Eae 1 91.12 High High
Antihistamine 2 81.28 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 84 100.00 Very High Very High Very High
Coronary Artery Disease 88 99.24 Very High Very High Very High
Headache 1 98.16 Very High Very High Very High
Pruritus 1 97.60 Very High Very High Very High
Pressure And Volume Under Development 12 97.20 Very High Very High Very High
Urticaria 6 96.76 Very High Very High Very High
Syncope 1 96.32 Very High Very High Very High
Hypersensitivity 3 96.04 Very High Very High Very High
Diarrhoea 1 95.96 Very High Very High Very High
Anaphylactic Hypersensitivity 2 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It exerts its pharmacologic effects through interactions with H1 and H2 cell surface receptors, which promote changes in vascular permeability, levels of cyclic nucleotides, neutrophil and eosinophil chemokinesis and chemotaxis, gastrointestinal secretion, and smooth muscle contraction.
H1 Binding (interactions) of in eosinophil
1) Confidence 0.47 Published 1983 Journal Clin Rev Allergy Section Abstract Doc Link 6201253 Disease Relevance 0.39 Pain Relevance 0.11
In this paper, the interactions between opiates and antihistaminic compounds, both H1- and H2-blockers, were studied.
H1 Binding (interactions) of associated with opiate
2) Confidence 0.36 Published 1990 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 1983158 Disease Relevance 0 Pain Relevance 0.44
It could be suggested that H1 blockers have a direct myogenic effect on guinea pig gastric fundus smooth muscle and might also interact postsynaptically with muscarinic receptors in this tissue.
H1 Spec (might) Binding (interact) of in smooth muscle
3) Confidence 0.30 Published 1996 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8721254 Disease Relevance 0 Pain Relevance 0.10
The results suggest that H1-blocking agents may specifically interact, though not necessarily directly, with opiate mechanisms in producing behavioural effects.
H1-blocking Neg (not) Binding (interact) of associated with opiate
4) Confidence 0.21 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2892221 Disease Relevance 0.17 Pain Relevance 0.44
It exerts its pharmacologic effects through interactions with H1 and H2 cell surface receptors, which promote changes in vascular permeability, levels of cyclic nucleotides, neutrophil and eosinophil chemokinesis and chemotaxis, gastrointestinal secretion, and smooth muscle contraction.
H1 Binding (interactions) of in neutrophil
5) Confidence 0.16 Published 1983 Journal Clin Rev Allergy Section Abstract Doc Link 6201253 Disease Relevance 0.39 Pain Relevance 0.11
Symptoms have typically been prevented by a combination of H1 and H2 antagonists, with addition of a cyclo-oxygenase inhibitor in syncopal cases.
H1 Binding (combination) of associated with antagonist
6) Confidence 0.10 Published 1987 Journal South. Med. J. Section Abstract Doc Link 2879359 Disease Relevance 1.67 Pain Relevance 0.20
A premedication with histamine H1 and H2 receptor antagonists was developed which in five controlled clinical trials blocked histamine-release responses of all grades of severity.
H1 Binding (premedication) of associated with antagonist
7) Confidence 0.10 Published 1985 Journal N Engl Reg Allergy Proc Section Abstract Doc Link 2442588 Disease Relevance 0.43 Pain Relevance 0.12
Three-dimensional structural analyses based on HA molecules cocrystallized with a sialylated glycan receptor analogue (pentasaccharide) suggest that molecular contacts between HA and the sialylated glycan receptor are divided into base and extension regions which include contacts with the terminal sialylgalactose moiety and the subsequent sugar rings, respectively [29],[30], and that the sialylated glycan molecules bind to H1 and H3 HAs in different conformations (i.e., the H1 HA glycan binding site in the extension region form different conformation from that of H3 HA) [27],[29],[30],[31],[32],[33].
H1 Binding (bind) of
8) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0 Pain Relevance 0
In the present study, we found that MAb S139/1 bound to all the strains of H1, H2, H3, H5, H9, and H13 subtypes tested by ELISA, whereas it showed neutralization and HI activities to some particular strains tested.
H1 Binding (bound) of associated with sprains and strains
9) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.37 Pain Relevance 0
Consistent with its reactivity profile in HI tests and ELISA, MAb S139/1 neutralized infectivity of WSN (H1), Adachi (H2), Aichi (H3), and Maryland (H13) strains.
H1 Binding (infectivity) of associated with sprains and strains
10) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.98 Pain Relevance 0
Relative neutralizing activities of MAb139/1 were also correlated with its reactivity to these viruses in the HI test and ELISA (i.e., MAb S139/1 neutralized Aichi (H3), WSN (H1), Adachi (H2), and Maryland (H13) in order of increasing activity).
H1 Binding (neutralized) of
11) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.83 Pain Relevance 0
A significant decrease in CSNA with i.v. lidocaine, 2 mg.kg BW-1 was recognized in Groups C and H-1, but not in Groups H-2 and H-3.
H-1 Binding (recognized) of associated with lidocaine
12) Confidence 0.06 Published 1994 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8171945 Disease Relevance 0 Pain Relevance 0.88
In addition to observing the association of a specific genotype presentation (H1/H1; H1/H2; H2/H2) on CAD, considering also the low number of H2/H2 subjects, we compare subjects homozygous for the wild-type allele with subjects carrying the minor allele, according to a dominant model.
H1 Binding (association) of associated with coronary artery disease
13) Confidence 0.01 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 0.10 Pain Relevance 0
In addition to observing the association of a specific genotype presentation (H1/H1; H1/H2; H2/H2) on CAD, considering also the low number of H2/H2 subjects, we compare subjects homozygous for the wild-type allele with subjects carrying the minor allele, according to a dominant model.
H1 Binding (association) of associated with coronary artery disease
14) Confidence 0.01 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 0.10 Pain Relevance 0

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