INT188434

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.17
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6R) extracellular region (IL6R) plasma membrane (IL6R)
enzyme binding (IL6R)
Anatomy Link Frequency
skin 1
IL6R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 106 90.48 High High
cytokine 57 86.52 High High
Pain 3 76.08 Quite High
anakinra 2 72.52 Quite High
Arthritis 12 50.00 Quite Low
Etanercept 1 48.44 Quite Low
methotrexate 4 44.36 Quite Low
chemokine 8 5.00 Very Low Very Low Very Low
visual analogue scale 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keloid Scars 206 98.38 Very High Very High Very High
INFLAMMATION 113 90.48 High High
Disease 56 89.28 High High
Fibrosis 6 88.92 High High
Fever 6 83.44 Quite High
Cancer 58 78.16 Quite High
Pain 1 76.08 Quite High
Benign Tumor 34 68.48 Quite High
Malignant Neoplastic Disease 6 66.52 Quite High
Amyloidosis 2 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with previous reports [5], [6], we have demonstrated that IL-6 is significantly up-regulated in keloid scars versus their normal skin counterparts, and KPCs constitutively express a higher level of IL-6 and IL-6R compared to SKPs.
Positive_regulation (level) of IL-6R in skin associated with keloid scars
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.46 Pain Relevance 0.31
In addition to the increase in serum IL-6, it has been found that there is a significant increase in soluble IL-6 receptor (sIL-6R) concentrations [15].
Positive_regulation (increase) of sIL-6R
2) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297576 Disease Relevance 0.44 Pain Relevance 0.15
Since KPCs constitutively expressed a higher level of IL-6 and IL-6R than SKPs (Figures 3G and 3H; Figure S4C), we next tested whether the intrinsically secreted IL-6 might contribute to the elevated telomerase expression and activity in KPCs.
Positive_regulation (level) of IL-6R
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.28 Pain Relevance 0.03

General Comments

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