INT188435

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SQSTM1) cytosol (SQSTM1) nucleoplasm (SQSTM1)
nucleus (SQSTM1) response to stress (SQSTM1) cytoplasm (SQSTM1)
PDB1 (Homo sapiens)
SQSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 73 100.00 Very High Very High Very High
Disease 13 100.00 Very High Very High Very High
Osteoporosis 1 69.72 Quite High
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Osteolysis 2 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that PDB-related SQSTM1 mutations may confer a higher susceptibility to development of the disease by impairing the binding of the p62 protein to a ubiquitinated target.
PDB Negative_regulation (impairing) of p62 protein Binding (binding) of associated with disease and bone disease
1) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 0.49 Pain Relevance 0

General Comments

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