INT18844

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 11.01
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
pancreatic beta cells 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 20 99.84 Very High Very High Very High
aspirin 8 99.42 Very High Very High Very High
COX2 1 99.28 Very High Very High Very High
Nucleus accumbens 3 95.60 Very High Very High Very High
cva 76 93.84 High High
Clonidine 4 91.20 High High
imagery 6 87.88 High High
beta blocker 5 87.68 High High
COX-2 inhibitor 53 59.80 Quite High
Inflammation 60 57.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 285 100.00 Very High Very High Very High
Diabetes Mellitus 242 100.00 Very High Very High Very High
Disease 180 100.00 Very High Very High Very High
Hypertension 17 100.00 Very High Very High Very High
Alzheimer's Dementia 13 100.00 Very High Very High Very High
Hyperinsulinism 3 100.00 Very High Very High Very High
INFLAMMATION 69 99.12 Very High Very High Very High
Aging 10 98.92 Very High Very High Very High
Compartment Syndromes 21 98.36 Very High Very High Very High
Hypoglycemia 61 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SAP and DAP recovery was partial in severe hypertensive subjects and complete in the other two groups.
DAP Spec (partial) Binding (complete) of associated with hypertension
1) Confidence 0.36 Published 1990 Journal Medicina (B Aires) Section Abstract Doc Link 1983221 Disease Relevance 0.64 Pain Relevance 0.24
Aspirin and diabetes: inhibition of amylin aggregation by nonsteroidal anti-inflammatory drugs.
amylin Binding (aggregation) of associated with aspirin, inflammation, diabetes mellitus and cinod
2) Confidence 0.36 Published 2003 Journal Exp. Clin. Endocrinol. Diabetes Section Title Doc Link 12605343 Disease Relevance 0.98 Pain Relevance 0.52
SAP and DAP reactivity were highest in severe hypertensive patients and lowest in normal subjects.
DAP Binding (reactivity) of associated with hypertension
3) Confidence 0.35 Published 1990 Journal Medicina (B Aires) Section Abstract Doc Link 1983221 Disease Relevance 0.65 Pain Relevance 0.25
ACS is the natural progression of pressure-induced end-organ changes and develops if IAP is not recognized and treated in a timely manner.
IAP Binding (recognized) of associated with compartment syndromes
4) Confidence 0.26 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2992055 Disease Relevance 1.25 Pain Relevance 0
Clinical case: A patient recently diagnosed with type 2 diabetes
diabetes Binding (diagnosed) of associated with diabetes mellitus
5) Confidence 0.22 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.85 Pain Relevance 0
Type 2 diabetes is a highly prevalent, progressive disease, characterized by defects in insulin production and utilization and is associated with significant morbidity and mortality.
diabetes Binding (associated) of associated with diabetes mellitus and disease
6) Confidence 0.21 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.85 Pain Relevance 0
Hyperinsulinemia, Insulin-like growth factor-1 (IGF-1), and Amylin (IAPP)
Amylin Binding (Hyperinsulinemia) of associated with hyperinsulinism
7) Confidence 0.18 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.83 Pain Relevance 0
antibodies raised against PLAP may cross-react with IAP

[29, 49] but this can be minimized by serum heat inactivation.

IAP Binding (react) of
8) Confidence 0.11 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.16 Pain Relevance 0.04
, and islet amyloid polypeptide deposits (AIAPP) are very strongly associated with both old age and the aging process.
islet amyloid polypeptide Binding (associated) of associated with aging and alzheimer's dementia
9) Confidence 0.09 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC1232862 Disease Relevance 1.78 Pain Relevance 0.28
Inhibitor of apoptosis (IAP) family, by directly interacting with caspases (i.e., XIAP, survivin [100]) controls and prevents their activity once cleaved.
IAP Binding (interacting) of associated with apoptosis
10) Confidence 0.06 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.29 Pain Relevance 0
Amylin binds to sites in pancreatic beta cells that may provide negative feedback inhibition of its own secretion and inhibits insulin release (Martinez et al 2000).
Amylin Binding (binds) of in pancreatic beta cells
11) Confidence 0.03 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.26 Pain Relevance 0.13
The pro-survival activity of IAPs, however, can in turn be inhibited by Smac/DIABLO that, once released from mitochondria, can bind IAP and promote activation of caspase-3.
IAP Binding (bind) of
12) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.40 Pain Relevance 0

General Comments

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