INT188448

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 3.75
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SQSTM1) cytosol (SQSTM1) nucleoplasm (SQSTM1)
nucleus (SQSTM1) response to stress (SQSTM1) cytoplasm (SQSTM1)
Anatomy Link Frequency
medial 1
CFPAC-1 1
SQSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 66 92.96 High High
Osteoarthritis 94 85.88 High High
imagery 16 80.00 Quite High
Glutamate 10 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 20 99.82 Very High Very High Very High
Focal Cartilage Defect 24 98.96 Very High Very High Very High
Hepatocellular Cancer 20 98.86 Very High Very High Very High
Repression 10 98.16 Very High Very High Very High
Bone Disease 103 96.56 Very High Very High Very High
Osteolysis 2 93.52 High High
Pain 66 92.96 High High
Syndrome 2 92.64 High High
Obesity 56 92.00 High High
Apoptosis 1 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of SQSTM1 is known to cause a decrease in NF-?
Negative_regulation (Depletion) of SQSTM1
1) Confidence 0.53 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.16 Pain Relevance 0
The increased protein level of Keap1 in cells depleted of SQSTM1 by RNAi was linked to a decrease in its rate of degradation; the half-life of Keap1 was almost doubled by RNAi depletion of SQSTM1.
Negative_regulation (depletion) of SQSTM1
2) Confidence 0.53 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
SQSTM1 was dispensable for the induction of the Keap1-Nrf2 pathway, as Nrf2 activation by tert-butylhydroquinone or iodoacetamide was not affected by RNAi depletion of SQSTM1.
Negative_regulation (depletion) of SQSTM1
3) Confidence 0.53 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
Furthermore, RNA interference (RNAi) depletion of SQSTM1 resulted in an increase in the protein level of Keap1 and a concomitant decrease in the protein level of Nrf2 in the absence of changes in Keap1 or Nrf2 mRNA levels.
Negative_regulation (depletion) of SQSTM1
4) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
Inactivation of the p62/SQSTM1 gene could activate the RANKĀ–NF?
Negative_regulation (Inactivation) of SQSTM1
5) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 1.54 Pain Relevance 0
In light of the observation of Komatsu and colleagues that ectopic expression of SQSTM1 causes a decrease in the ubiquitination of Nrf2, and in turn an increase in the total cellular level of the transcription factor (23), it is plausible that the decrease in total cellular level of Nrf2 following siRNA depletion of SQSTM1 reported here is due to an increase in Keap1-directed ubiquitination of Nrf2, facilitated by the higher basal level of Keap1.
Negative_regulation (depletion) of SQSTM1
6) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.07 Pain Relevance 0
The increased protein level of Keap1 in cells depleted of SQSTM1 by RNAi was linked to a decrease in its rate of degradation; the half-life of Keap1 was almost doubled by RNAi depletion of SQSTM1.
Negative_regulation (depleted) of SQSTM1
7) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
The decreased level of Nrf2 in cells depleted of SQSTM1 by RNAi was associated with decreases in the mRNA levels, protein levels, and function of several Nrf2-regulated cell defense genes.
Negative_regulation (depleted) of SQSTM1
8) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
B activity (22), and we have shown here that depletion of SQSTM1 is associated with an induction of Keap1 and repression of Nrf2.
Negative_regulation (depletion) of SQSTM1 associated with repression
9) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.17 Pain Relevance 0
In HeLa (cervical adenocarcinoma), HEK293T (kidney), HepG2 (hepatocellular carcinoma), Huh-7 (hepatocellular carcinoma), and CFPAC-1 (pancreatic ductal adenocarcinoma) cells, depletion of SQSTM1 with si-SQSTM1 h3 consistently resulted in a increase in the basal protein level of Keap1 (Fig. 2A).
Negative_regulation (depletion) of SQSTM1 in CFPAC-1 associated with adenocarcinoma and hepatocellular cancer
10) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.39 Pain Relevance 0
Given that siRNA depletion of SQSTM1 resulted in a decrease in the basal protein level of Nrf2, we hypothesized that this would correspond to a decrease in the capacity of Nrf2-regulated cell defense processes.
Negative_regulation (depletion) of SQSTM1
11) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
There was no difference in PWC170 at baseline between the two groups, but offspring had significantly greater decrease in PWC170 during follow-up.
Negative_regulation (decrease) of PWC170
12) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526579 Disease Relevance 0.25 Pain Relevance 0.09
In comparison with controls, offspring had higher annual knee cartilage loss (-3.1% versus -2.0% at medial tibial site, -1.9% versus -1.1% at lateral tibial site and -4.7% versus -3.7% at patellar site, all P < 0.05), a greater increase in medial cartilage defect score (+0.15 versus -0.01, P < 0.05) and a greater decline in PWC170 (-0.7 watts/kg versus -0.4 watts/kg, P < 0.01).
Negative_regulation (decline) of PWC170 in medial associated with focal cartilage defect
13) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526579 Disease Relevance 1.17 Pain Relevance 0.45

General Comments

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