INT188449

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 11.29
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ENPEP) peptidase activity (ENPEP) cell-cell signaling (ENPEP)
Anatomy Link Frequency
chondrocytes 2
neuron 1
internal 1
ENPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 127 99.84 Very High Very High Very High
Fibrositis 423 99.64 Very High Very High Very High
Pain 60 85.12 High High
allodynia 9 82.72 Quite High
spastic colon 27 81.00 Quite High
headache 27 79.96 Quite High
Restless leg syndrome 18 79.36 Quite High
depression 20 79.24 Quite High
backache 9 78.44 Quite High
Myofascial pain syndrome 9 76.76 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 423 99.64 Very High Very High Very High
Disease 112 99.36 Very High Very High Very High
Bone Disease 146 98.84 Very High Very High Very High
Fatigue 63 97.40 Very High Very High Very High
Autoimmune Disease 36 97.08 Very High Very High Very High
Syndrome 58 90.28 High High
Pain 68 85.12 High High
Pharyngitis 27 84.68 Quite High
Infection 15 83.52 Quite High
Neuropathic Pain 9 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a positive correlation between APA and IL-1 levels in the patient subgroup with APA >30 U, which might be associated with an immunological response to environmental agents in some way related to polymerized acrylamide.
Gene_expression (levels) of APA
1) Confidence 0.55 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 0.76 Pain Relevance 0.17
APA levels were determined on serum samples by an indirect ELISA kit that detects IgG APA.
Gene_expression (detects) of APA
2) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212586 Disease Relevance 0.97 Pain Relevance 0.57
The production of APA antibodies may result from an immunological response to self-antigens or to environmental agents, such as medications, silicone, or other chemicals, which results in the formation of antibodies cross-reacting with partially polymerized acrylamide.
Gene_expression (production) of APA
3) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 0.93 Pain Relevance 0.36
Interestingly, in our study the APA levels correlated with Fibromyalgia Impact Questionnaire estimates and tiredness results in the subset of seropositive patients, so APA correlated with the severity of the disease only when it is positive.
Gene_expression (levels) of APA associated with fatigue, disease and fibrositis
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 0.89 Pain Relevance 0.29
Our objective was to examine the presence of APA seropositivity in 285 nonimplanted FM patients and to verify whether APA levels correlate with disease severity and with cytokine levels.
Spec (whether) Gene_expression (levels) of APA associated with disease, fibrositis and cytokine
5) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 0.76 Pain Relevance 0.31
APA-seropositive patients exhibited significant correlations between APA levels and the Fibromyalgia Impact Questionnaire estimate (P = 0.042), tiredness (P = 0.003) and IL-1 levels (P = 0.0072).
Gene_expression (levels) of APA associated with fatigue and fibrositis
6) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212586 Disease Relevance 1.41 Pain Relevance 0.68
APA levels were determined on serum samples by an indirect ELISA kit that detects IgG APA (Corgenix, Westminster, CO, USA), according to the manufacturer's instructions.
Gene_expression (detects) of APA
7) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 1.76 Pain Relevance 0.73
We did not find differences of seropositivity between FM patients and control individuals but did observe that patients with moderate and severe symptoms exhibited qualitatively higher levels of APA, even if not statistically significant, with respect to patients with mild symptoms.
Gene_expression (levels) of APA associated with fibrositis
8) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 0.59 Pain Relevance 0.26
The presence of APA, however, might permit the identification of a subset of FM patients with more severe symptoms and of patients who may respond differently to different therapeutic strategies.



Gene_expression (presence) of APA associated with fibrositis
9) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212586 Disease Relevance 1.24 Pain Relevance 0.58
PSA: Puromycin-sensitive aminopeptidase; GST: Glutathione S-transferase; MBP: maltose binding protein; E-64: trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane; DDT: dithiothreitol; MNA: 4-methoxy-2-naphthylamide; PMSF: phenylmethylsulfonylfluride

Competing interests

Gene_expression (sensitive) of aminopeptidase
10) Confidence 0.11 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.07 Pain Relevance 0
This finding shows that Tau cleavage was internal, not expected for an aminopeptidase.
Neg (not) Gene_expression (expected) of aminopeptidase in internal
11) Confidence 0.11 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0
Although bone scanning is commonly recommended in patients with PDB older than 40 years of age, because of the ethical considerations observed in our country, bone scan tests cannot be performed unless AP levels are raised and consequently PDB bone localization cannot be excluded at this stage in asymptomatic mutant carriers.
Gene_expression (levels) of AP associated with bone disease
12) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 0.91 Pain Relevance 0
So far the asymptomatic gene carriers have not exhibited any abnormality in the circulating levels of AP and have not shown any clinical signs suggestive of PDB.
Gene_expression (levels) of AP associated with bone disease
13) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 1.03 Pain Relevance 0
Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes

The aim of this study was to determine the effects of glucosamine on matrix metalloprotease (MMP) production, on mitogen-activated protein kinase (MAPK) phosphorylation, and on activator protein (AP)-1 transcription factor activation in human chondrocytes.

Spec (determine) Gene_expression (determine) of AP in chondrocytes
14) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0
Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes

The aim of this study was to determine the effects of glucosamine on matrix metalloprotease (MMP) production, on mitogen-activated protein kinase (MAPK) phosphorylation, and on activator protein (AP)-1 transcription factor activation in human chondrocytes.

Spec (determine) Gene_expression (production) of AP in chondrocytes
15) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0
If the AP from neuron "A" activates neuron "B" and neuron B's AP travels subsequently in the opposite direction to the AP from neuron A, the initiation of the AP in B will have the same polarity as the termination of the AP of B.
Gene_expression (travels) of AP in neuron
16) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

General Comments

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