INT188471

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.61
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Gpi1, Arhgap4) nucleus (Gpi1, Arhgap4) isomerase activity (Gpi1)
Golgi apparatus (Arhgap4) carbohydrate metabolic process (Gpi1) cytosol (Gpi1)
Anatomy Link Frequency
cartilage 1
Gpi1 (Mus musculus)
Arhgap4 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 96 96.60 Very High Very High Very High
spinal inflammation 4 78.00 Quite High
Inflammation 12 74.48 Quite High
rheumatoid arthritis 12 54.56 Quite High
Disease Link Frequency Relevance Heat
Arthritis 102 96.60 Very High Very High Very High
Sprains And Strains 25 86.76 High High
Targeted Disruption 7 78.76 Quite High
Low Back Pain 4 78.00 Quite High
INFLAMMATION 10 74.48 Quite High
Pressure And Volume Under Development 4 73.48 Quite High
Ankylosis 1 70.88 Quite High
Immunization 16 68.16 Quite High
Rheumatoid Arthritis 12 54.56 Quite High
Syndrome 4 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is no evidence for a cross-reactivity between G6PI and CII, and the most likely explanation is an activation of an autoimmune response to cartilage-derived CII, as has been seen in pristine-induced arthritis and in various spontaneous arthritides in mice [38-41].
G6PI Spec (likely) Binding (reactivity) of CII in cartilage associated with arthritis
1) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.61 Pain Relevance 0.58

General Comments

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