INT188498

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 0.14
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 7 93.76 High High
Potency 32 73.64 Quite High
agonist 42 50.00 Quite Low
Inflammatory mediators 2 30.24 Quite Low
long-term potentiation 49 5.00 Very Low Very Low Very Low
Inflammation 46 5.00 Very Low Very Low Very Low
anesthesia 35 5.00 Very Low Very Low Very Low
gABA 21 5.00 Very Low Very Low Very Low
Versed 14 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 6 72.04 Quite High
Apoptosis 9 31.00 Quite Low
INFLAMMATION 56 29.84 Quite Low
Amnesia 28 5.00 Very Low Very Low Very Low
Sleep Disorders 14 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low
Aids-related Complex 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both lower and higher doses of propofol resulted in significant decrease of Egr-1 transcription, 87% ± 5% (P = 0.032, N = 3) and 94% ± 3% (P = 0.008, N = 3) decrease for 5.6 ?
Negative_regulation (decrease) of Transcription (transcription) of Egr-1
1) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
M) propofol caused a 80% induction in c-Fos transcription, and a 91% decrease in the transcription of Egr-1.
Negative_regulation (decrease) of Transcription (transcription) of Egr-1
2) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
M propofol resulted in 91% ± 4% fold (P = 0.006, N = 3) inhibition in Egr-1 transcription.
Negative_regulation (inhibition) of Transcription (transcription) of Egr-1
3) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
M propofol resulted in 91% ± 4% (P = 0.006, N = 3) decrease in Egr-1 transcription.
Negative_regulation (decrease) of Transcription (transcription) of Egr-1
4) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.03
In contrast, propofol significantly reduced the transcription of Egr-1 in all concentrations including both lower concentration of 5.6 ?
Negative_regulation (reduced) of Transcription (transcription) of Egr-1
5) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
Both lower and higher doses of propofol resulted in significant decrease of Egr-1 transcription, 87% ± 5% (P = 0.032, N = 3) and 94% ± 3% (P = 0.008, N = 3) decrease for 5.6 ?
Negative_regulation (decrease) of Transcription (transcription) of Egr-1
6) Confidence 0.41 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.05
The transcription of c-Fos (Figure 1A) peaked between 30 and 60 min of exposure and rapidly returned to control levels while the transcription of Egr-1 (Figure 1B) decreased and reached the minimum at 240 min.
Negative_regulation (decreased) of Transcription (transcription) of Egr-1
7) Confidence 0.36 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
was shown to be closely dependent on the transcription factor early growth response factor-1 (Egr-1) [57], although activator protein-1 and specificity protein-1 binding sites were also found [62].
Negative_regulation (dependent) of Transcription (transcription) of Egr-1
8) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.04
was shown to be closely dependent on the transcription factor early growth response factor-1 (Egr-1) [57], although activator protein-1 and specificity protein-1 binding sites were also found [62].
Negative_regulation (dependent) of Transcription (transcription) of early growth response factor-1
9) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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