INT18853

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.51
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (APCS) protein folding (APCS) extracellular space (APCS)
extracellular region (APCS) protein complex (APCS)
Anatomy Link Frequency
platelet 1
Respiratory 1
APCS (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 3 99.90 Very High Very High Very High
Clonidine 12 99.62 Very High Very High Very High
Pain 2 93.68 High High
pruritus 2 89.80 High High
anesthesia 15 86.92 High High
Dopamine 58 86.80 High High
intrathecal 4 82.72 Quite High
Acupuncture 1 72.16 Quite High
agonist 3 57.60 Quite High
Inflammation 14 53.08 Quite High
Disease Link Frequency Relevance Heat
Intestinal Polyps 2 100.00 Very High Very High Very High
Respiratory Failure 3 99.90 Very High Very High Very High
Hypoxia 56 99.16 Very High Very High Very High
Glaucoma 51 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 15 98.44 Very High Very High Very High
Pressure And Volume Under Development 4 96.56 Very High Very High Very High
Disease Progression 3 95.84 Very High Very High Very High
Injury 10 94.16 High High
Pain 2 93.68 High High
Hypertension 10 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maximum decrease in SAP was smaller in the 30-mg group (mean lowest SAP 87% of baseline, range 58%-105%) compared with other groups (P < 0.01).
Negative_regulation (decrease) of SAP
1) Confidence 0.57 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10825326 Disease Relevance 0.47 Pain Relevance 0.20
Esmolol decreased HR, systolic, mean and diastolic SAP in anesthetized monkeys while only HR, systolic and mean SAP achieved a statistically significant decrease in the conscious model.
Negative_regulation (decreased) of SAP
2) Confidence 0.51 Published 2008 Journal J Pharmacol Toxicol Methods Section Body Doc Link 18583160 Disease Relevance 0 Pain Relevance 0
In all groups SAP decreased significantly below baseline levels for the duration of the measurements (15 min after drug administration), except for the lower dose of thiopental, where SAP returned to baseline values within 10 min.
Negative_regulation (decreased) of SAP
3) Confidence 0.42 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1984373 Disease Relevance 0.29 Pain Relevance 0.16
There were significant decreases in SAP (p < 0.0001), MAP (p < 0.0005), and DAP (p < 0.0008) after butorphanol administration in group 2.
Negative_regulation (decreases) of SAP
4) Confidence 0.42 Published 2008 Journal Vet Anaesth Analg Section Body Doc Link 17696970 Disease Relevance 0 Pain Relevance 0
The incidence of hypotension (SAP decrease >30% from baseline) was higher in the conventional (22.4%) than unilateral group (5%) (P < .01).
Negative_regulation (decrease) of SAP
5) Confidence 0.42 Published 1999 Journal Reg Anesth Pain Med Section Body Doc Link 10338170 Disease Relevance 0 Pain Relevance 0
Respiratory depression and decreases in SAP were observed 5-50 min after meperidine injection.
Negative_regulation (decreases) of SAP in Respiratory associated with depression and respiratory failure
6) Confidence 0.41 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10195532 Disease Relevance 0.72 Pain Relevance 0.69
The amplitude of SAP reduction was greater in anesthetized models, while the amplitude of HR reduction was greater in the conscious and anesthetized cynomolgus models than in the anesthetized rhesus model.
Negative_regulation (reduction) of SAP
7) Confidence 0.38 Published 2008 Journal J Pharmacol Toxicol Methods Section Body Doc Link 18583160 Disease Relevance 0 Pain Relevance 0
Cells were then stimulated for 24 hrs in the presence or absence of platelet-derived growth factor (PDGF) antibody (200 ng/mL) and/or SAP (1 or 4 ?
Negative_regulation (absence) of SAP in platelet
8) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0 Pain Relevance 0
The dose of clonidine per m2BSA able to reduce by 10% either SAP or DAP (active dose-10), and the dose able to reduce SAP or DAP by 10 mmHg in one minute (systolic or diastolic clonidine unit) were calculated, providing indices for detecting clonidine responsiveness in patients with exaggerated hypertension.
Negative_regulation (reduce) of SAP associated with hypertension and clonidine
9) Confidence 0.17 Published 1983 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6628497 Disease Relevance 0.49 Pain Relevance 0.52
Recently, a change in the diagnostic criteria of glaucoma has been promoted such that glaucoma diagnosis may be made before the old prerequisites’ functional criteria of standard automatic perimetry visual field (SAP- VF) loss are apparent, namely ‘preperimetric glaucoma' (PPG).
Negative_regulation (loss) of SAP associated with glaucoma
10) Confidence 0.13 Published 2010 Journal The Open Ophthalmology Journal Section Body Doc Link PMC2928913 Disease Relevance 1.19 Pain Relevance 0
The dose of clonidine per m2BSA able to reduce by 10% either SAP or DAP (active dose-10), and the dose able to reduce SAP or DAP by 10 mmHg in one minute (systolic or diastolic clonidine unit) were calculated, providing indices for detecting clonidine responsiveness in patients with exaggerated hypertension.
Negative_regulation (reduce) of SAP associated with hypertension and clonidine
11) Confidence 0.11 Published 1983 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6628497 Disease Relevance 0.49 Pain Relevance 0.52
In the presence of a lowered SAP/PAP ratio, owing to hypoxic pulmonary vasoconstriction, epinephrine did not alter the ratio but did increase cardiac output and therefore oxygen delivery.
Negative_regulation (lowered) of SAP associated with hypoxia and increased venous pressure under development
12) Confidence 0.11 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.41 Pain Relevance 0.19
Two of the celecoxib studies were on the prevention of intestinal polyps (APC and pre-SAP) and one placebo controlled study of both celecoxib and naproxen examined the prevention of Alzheimers disease progression (ADAPT).
Negative_regulation (prevention) of pre-SAP associated with intestinal polyps and disease progression
13) Confidence 0.00 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376081 Disease Relevance 0.45 Pain Relevance 0.03

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