INT188563

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TLR4, PRF1) endosome (PRF1) signal transduction (TLR4)
extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1) intracellular (TLR4)
Anatomy Link Frequency
T cells 2
TLR4 (Homo sapiens)
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 31 98.76 Very High Very High Very High
Arthritis 16 86.48 High High
rheumatoid arthritis 20 85.92 High High
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 31 98.76 Very High Very High Very High
Disease 8 94.12 High High
Seronegative Spondarthritis 16 86.88 High High
Rheumatoid Arthritis 20 85.92 High High
Cancer 4 64.88 Quite High
Necrosis 4 64.60 Quite High
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis

CD3+CD4+CD28null and CD3+CD8+CD28null T cells are enriched in patients with immune-mediated diseases compared with healthy controls.

TLR4 Positive_regulation (mediated) of Gene_expression (production) of perforin in T cells associated with spinal inflammation and disease
1) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1297589 Disease Relevance 0.78 Pain Relevance 0.36

General Comments

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