INT188564

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) DNA binding (IRF6) cytoplasm (IRF6)
cytosol (IRF6) extracellular region (PRF1) nucleus (IRF6)
Anatomy Link Frequency
T cells 4
IRF6 (Homo sapiens)
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 62 84.72 Quite High
rheumatoid arthritis 40 13.92 Low Low
Arthritis 32 13.56 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 62 84.72 Quite High
Rheumatoid Arthritis 40 13.92 Low Low
Seronegative Spondarthritis 32 13.56 Low Low
Disease 16 6.72 Low Low
Necrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking assays with antibodies directed against TLR4 were then performed to specifically address the role of TLR4 in LPS-mediated perforin production of CD4+CD28null T cells.
LPS Positive_regulation (mediated) of Gene_expression (production) of perforin in T cells
1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.20 Pain Relevance 0.20
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
LPS Positive_regulation (induced) of Gene_expression (production) of perforin in T cells
2) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24

General Comments

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