INT188566

Context Info Confidence 0.01 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.20

plasma membrane (TLR4, PRF1) endosome (PRF1) signal transduction (TLR4) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1) intracellular (TLR4)

Anatomy Link Frequency T cells 2 TLR4 (Homo sapiens) PRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 31 72.40 rheumatoid arthritis 20 5.00 Arthritis 16 5.00 cytokine 5 5.00 Inflammation 2 5.00 tolerance 1 5.00 Infliximab 1 5.00

Disease Link Frequency Relevance Heat Low Back Pain 31 72.40 Disease 8 6.72 Rheumatoid Arthritis 20 5.00 Seronegative Spondarthritis 16 5.00 Necrosis 4 5.00 Cancer 4 5.00 INFLAMMATION 2 5.00 Sprains And Strains 1 5.00 Syndrome 1 5.00 Body Weight 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blocking assays with antibodies directed against TLR4 were then performed to specifically address the role of TLR4 in LPS-mediated perforin production of CD4+CD28null T cells.

TLR4 Regulation (role) of Gene_expression (production) of perforin in T cells

1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.20 Pain Relevance 0.20

General Comments

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