INT188567

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6, CD28) plasma membrane (CD28) nucleus (IRF6)
DNA binding (IRF6) cytoplasm (IRF6)
Anatomy Link Frequency
T cells 4
IRF6 (Homo sapiens)
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 62 96.84 Very High Very High Very High
Arthritis 32 93.44 High High
rheumatoid arthritis 40 92.52 High High
Inflammation 4 92.28 High High
cytokine 10 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 62 96.84 Very High Very High Very High
Seronegative Spondarthritis 32 93.44 High High
Rheumatoid Arthritis 40 92.52 High High
INFLAMMATION 4 92.28 High High
Sprains And Strains 2 54.64 Quite High
Disease 16 53.44 Quite High
Necrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiments both the addition of recombinant sCD14 and autologous serum had a comparable additional effect on LPS-induced perforin production of CD4+CD28null T cells, which indicates serum LPS binding protein not to be indispensable in AS.
LPS Neg (not) Positive_regulation (induced) of Neg (not) Gene_expression (production) of CD28null in T cells associated with spinal inflammation
1) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.59 Pain Relevance 0.40
LPS-mediated perforin production of CD4+CD28null T cells depends on CD14 and TLR4
LPS Positive_regulation (mediated) of Gene_expression (production) of CD28null in T cells
2) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.70 Pain Relevance 0.43

General Comments

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