INT18857

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.62
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
plasma 4
SCP 2
ventromedial hypothalamic nucleus 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 59 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Chronic pancreatitis 8 98.80 Very High Very High Very High
depression 1 98.80 Very High Very High Very High
tetrodotoxin 2 98.60 Very High Very High Very High
qutenza 12 98.40 Very High Very High Very High
antagonist 7 96.30 Very High Very High Very High
opiate 8 95.90 Very High Very High Very High
Endogenous opioid 4 84.40 Quite High
amygdala 3 75.12 Quite High
Disease Link Frequency Relevance Heat
Aging 2 99.56 Very High Very High Very High
Steatorrhea 4 99.22 Very High Very High Very High
Pancreatitis 8 98.80 Very High Very High Very High
Depression 1 98.80 Very High Very High Very High
Appetite Loss 2 95.80 Very High Very High Very High
Weight Loss 1 94.32 High High
Reprotox - General 1 3 90.84 High High
Acne 1 88.88 High High
Weight Gain 5 88.56 High High
Malabsorption Syndromes 1 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vagotomy or perivagal application of capsaicin, a sensory neurotoxin, abolished increases in pancreatic secretion but not plasma CCK levels in response to diversion of bile pancreatic secretion or duodenal administration of casein.
Neg (not) Negative_regulation (abolished) of Positive_regulation (increases) of CCK in plasma
1) Confidence 0.59 Published 1994 Journal Gastroenterology Section Body Doc Link 8039628 Disease Relevance 0 Pain Relevance 0
In addition, continuous intraduodenal infusion of trypsin prevented the increase in plasma CCK levels and pancreatic wet weight after capsaicin treatment.
Negative_regulation (prevented) of Positive_regulation (increase) of CCK in plasma associated with qutenza and cholecystokinin
2) Confidence 0.59 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12801885 Disease Relevance 0 Pain Relevance 1.20
Simultaneous infusion of trypsin with ovalbumin or casein hydrolysate reduced by approximately 60% the CCK release induced by peptone alone.
Negative_regulation (reduced) of Positive_regulation (induced) of CCK associated with cholecystokinin
3) Confidence 0.41 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2382718 Disease Relevance 0 Pain Relevance 0.54
Peak fluorescein serum concentration in patients with CP and steatorrhea (SCP) (n = 6) was < 2.5 micrograms/ml, and CCK and PP responses to the meal were significantly impaired (CCK response = 61 +/- 14 pmol/l/120 min in SCP vs. 110 +/- 14 in controls, P < 0.05; PP response = 3920 +/- 1773 pg/ml/120 min in SCP vs. 13418 +/- 3299 in controls, P < 0.05).
Negative_regulation (impaired) of Positive_regulation (responses) of CCK in SCP associated with steatorrhea, cholecystokinin and chronic pancreatitis
4) Confidence 0.41 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 8159806 Disease Relevance 1.00 Pain Relevance 0.96
The universal opiate receptor antagonist naltrexone and the delta-opiate receptor antagonist naltrindole each potentiated the estrogen-induced increase and elevated cholecystokinin messenger RNA levels an additional 1.9- to 2.8-fold depending on the nucleus examined, but had no effect on the estrogen-induced expression of either preproenkephalin or preprotachykinin messenger RNA. beta-Funaltrexamine, a mu-opiate receptor antagonist, had no effect on the medial preoptic or medial amygdaloid cholecystokinin messenger RNA levels or on the estrogen-induced expression of preproenkephalin messenger RNA but did cause a decrease in estrogen-induced cholecystokinin messenger RNA levels in the bed nucleus of the stria terminalis and a decrease in the preprotachykinin messenger RNA levels in the ventromedial hypothalamic nucleus.
Negative_regulation (decrease) of Positive_regulation (induced) of cholecystokinin in ventromedial hypothalamic nucleus associated with antagonist, opiate and cholecystokinin
5) Confidence 0.36 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284350 Disease Relevance 0 Pain Relevance 1.32
The results of studies in animals suggest that aging is associated with a decrease in the opioid feeding drive and an increase in the satiating effect of cholecystokinin.
Negative_regulation (decrease) of Positive_regulation (increase) of cholecystokinin associated with aging, cholecystokinin and opioid
6) Confidence 0.35 Published 1988 Journal Ann. Intern. Med. Section Abstract Doc Link 3056165 Disease Relevance 0.72 Pain Relevance 0.20
Cholecystokinin octapeptide-induced increases in short-circuit current were halved by removal of serosal buffer Ca2+ and were abolished in Cl(-)- and HCO3(-)-free buffer.
Negative_regulation (abolished) of Positive_regulation (increases) of Cholecystokinin associated with cholecystokinin
7) Confidence 0.31 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1985032 Disease Relevance 0 Pain Relevance 0.62
Researchers in Sweden recorded the secretion of the satiety hormone cholecystokinin during a 24-hour period before and during administration of OCs to 9 women, and found that pills suppressed the serum profiles of cholecystokinin inducing the feeling of hunger.
Negative_regulation (suppressed) of Positive_regulation (inducing) of cholecystokinin associated with cholecystokinin
8) Confidence 0.17 Published 1992 Journal Contracept Technol Update Section Abstract Doc Link 12344723 Disease Relevance 0.91 Pain Relevance 0.21

General Comments

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