INT188573

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (CD4) DNA binding (IRF6) cytoplasm (IRF6)
cytosol (IRF6) signal transduction (CD4) cell adhesion (CD4)
Anatomy Link Frequency
T cells 1
IRF6 (Homo sapiens)
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 31 66.60 Quite High
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Arthritis 16 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 31 66.60 Quite High
Disease 8 17.76 Low Low
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 16 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 5c, preincubation with anti-TLR4 antibody inhibited activation of CD4+CD28null T cells by LPS (3.4 ± 2.3% with anti-TLR4 antibody versus 23.8 ± 14.7% perforin+ cells with isotype control antibody, P = 0.002).


LPS Positive_regulation (activation) of CD4 in T cells
1) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.19 Pain Relevance 0.19

General Comments

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