INT188581

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1)
plasma membrane (PRF1)
Anatomy Link Frequency
T cells 2
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 62 86.80 High High
rheumatoid arthritis 40 85.72 High High
Arthritis 32 84.72 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 91.12 High High
Necrosis 8 90.56 High High
Low Back Pain 62 86.80 High High
Rheumatoid Arthritis 40 85.72 High High
Seronegative Spondarthritis 32 84.72 Quite High
Disease 16 77.04 Quite High
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perforin production could be prevented with blocking antibodies directed against CD14 or TLR4.
Negative_regulation (prevented) of Gene_expression (production) of Perforin
1) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297589 Disease Relevance 0.83 Pain Relevance 0.33
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
Negative_regulation (reversed) of Gene_expression (production) of perforin in T cells
2) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24

General Comments

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