INT188582

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.07
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
T cells 2
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 60 93.36 High High
Arthritis 20 92.52 High High
spinal inflammation 31 91.68 High High
Inflammatory response 28 83.52 Quite High
Inflammation 66 74.72 Quite High
ischemia 4 73.12 Quite High
cytokine 9 63.72 Quite High
Infliximab 9 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 324 99.40 Very High Very High Very High
Rheumatoid Arthritis 60 93.36 High High
Seronegative Spondarthritis 16 92.52 High High
Low Back Pain 31 91.68 High High
Autoimmune Disease 8 88.48 High High
Rheumatic Diseases 16 86.72 High High
INFLAMMATION 98 83.52 Quite High
Cv Unclassified Under Development 4 73.12 Quite High
Reperfusion Injury 4 72.40 Quite High
Lung Injury 8 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, TLR4 mRNA expression levels were elevated in PBMCs from patients, irrespective of disease activity (Figure 2b) and HLA-B51 phenotype (data not shown).
Positive_regulation (elevated) of Transcription (levels) of TLR4 associated with disease
1) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.60 Pain Relevance 0
The results indicate that TLR4 mRNA expression is constitutively increased in PBMCs from BD patients.


Positive_regulation (increased) of Transcription (expression) of TLR4 associated with disease
2) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.59 Pain Relevance 0.04
On the other hand, TLR4 mRNA expression levels were elevated in PBMCs from patients, irrespective of disease activity (Figure 2b) and HLA-B51 phenotype (data not shown).
Positive_regulation (elevated) of Transcription (expression) of TLR4 associated with disease
3) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.60 Pain Relevance 0
Our findings demonstrated that levels of TLR4 mRNA, but not of TLR2 mRNA, are constitutively increased in PBMCs from patients with BD, regardless of disease activity.
Positive_regulation (increased) of Transcription (levels) of TLR4 associated with disease
4) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.36 Pain Relevance 0.11
To test T cells for the expression of TLR2 and TLR4 mRNA, monocyte-depleted CD4+CD28null and CD4+CD28+ T cells were isolated from patients as well as from healthy controls (CD4+CD28+ T cells).
Positive_regulation (test) of Transcription (expression) of TLR4 in T cells
5) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.93 Pain Relevance 0.62

General Comments

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