INT188584

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.98
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
MD2 2
liver 2
mononuclear cells 2
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 412 99.96 Very High Very High Very High
antagonist 9 98.24 Very High Very High Very High
addiction 3 93.20 High High
agonist 164 85.44 High High
rheumatoid arthritis 40 85.36 High High
Inflammatory response 120 84.88 Quite High
Inflammatory marker 3 82.32 Quite High
spinal inflammation 31 79.68 Quite High
cytokine 183 78.48 Quite High
Arthritis 23 77.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 531 99.96 Very High Very High Very High
Necrosis 24 99.72 Very High Very High Very High
Cancer 18 99.54 Very High Very High Very High
Disease 162 98.84 Very High Very High Very High
Alcoholic Liver Diseases 6 95.92 Very High Very High Very High
Endotoxemia 10 93.92 High High
Injury 141 93.48 High High
Fatty Liver 9 91.76 High High
Hepatotoxicity 12 89.44 High High
Autoimmune Disease 10 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intake of high levels of fructose results in high triglyceride levels in plasma and their deposition in liver, as well as intestinal bacterial overgrowth and increased intestinal permeability, leading to elevated endotoxins and activation of TLR4 signaling [99,100].


Positive_regulation (elevated) of Positive_regulation (activation) of TLR4 in liver
1) Confidence 0.65 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.15 Pain Relevance 0.42
We test the hypothesis that the pro-inflammatory signaling indirectly stimulates the transcriptional activation of endotoxin receptor (TLR4); which quantitatively is expressed by the linear function (HP,R), (4b).
Positive_regulation (stimulates) of Positive_regulation (activation) of TLR4 associated with inflammation
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.18 Pain Relevance 0.16
DAMP activation of Toll-like receptors (TLRs) induces inflammatory gene expression to mediate tissue repair.
Positive_regulation (induces) of Positive_regulation (activation) of Toll associated with inflammation
3) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2913853 Disease Relevance 0.98 Pain Relevance 0.29
Removal of these acylated SFAs from lipid A not only results in complete loss of endotoxic activity, but also makes the deacylated lipid A act as an antagonist to native lipid A, suggesting that the FAs that are acylated in lipid A play a crucial role in ligand recognition and receptor activation for TLR4.
Positive_regulation (role) of Positive_regulation (activation) of TLR4 associated with antagonist
4) Confidence 0.47 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.32 Pain Relevance 0.21
Human MD2 is an accessory molecule expressed on the cell surface that is not only required for cell-surface expression of TLR4, but also appears to be essential for the activation of the TLR4 signaling cascade.
Positive_regulation (required) of Positive_regulation (activation) of TLR4 in MD2
5) Confidence 0.44 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0 Pain Relevance 0
Future experiments will elucidate the exact mechanisms of STAT3 involvement, and possibly other factors, in PAF mediated transcriptional activation of TLR4 and will investigate experimental models where PAF is neutralized.
Positive_regulation (mediated) of Positive_regulation (activation) of TLR4
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.47 Pain Relevance 0.16
PAF stimulation resulted in increased human TLR4 promoter activation in a dose dependent manner.
Positive_regulation (resulted) of Positive_regulation (activation) of TLR4
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955554 Disease Relevance 0.34 Pain Relevance 0
PAF stimulation resulted in increased human TLR4 promoter activation in a dose dependent manner.
Positive_regulation (increased) of Positive_regulation (activation) of TLR4
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955554 Disease Relevance 0.34 Pain Relevance 0
Our findings demonstrated that levels of TLR4 mRNA, but not of TLR2 mRNA, are constitutively increased in PBMCs from patients with BD, regardless of disease activity.
Positive_regulation (increased) of Positive_regulation (increased) of TLR4 associated with disease
9) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.36 Pain Relevance 0.11
Incubation of peripheral blood mononuclear cells with tumour necrosis factor alpha led to an upregulation of TLR4 and TLR2 on CD4+CD28null T cells in vitro, and treatment of patients with antibodies specifically directed against tumour necrosis factor alpha resulted in decreased expression of TLR4 and TLR2 on CD4+CD28null T cells in vivo.
Positive_regulation (led) of Positive_regulation (upregulation) of TLR4 in mononuclear cells associated with necrosis and cancer
10) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297589 Disease Relevance 0.84 Pain Relevance 0.30

General Comments

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