INT188585

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1)
plasma membrane (PRF1)
Anatomy Link Frequency
T cells 4
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 40 81.48 Quite High
Arthritis 32 81.12 Quite High
spinal inflammation 62 80.48 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 40 81.48 Quite High
Seronegative Spondarthritis 32 81.12 Quite High
Low Back Pain 62 80.48 Quite High
Disease 16 53.32 Quite High
Necrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4a,b, perforin was produced upon LPS stimulation by CD4+CD28null T cells (13 ± 10.7% perforin+ cells), but perforin expression was negligible in CD4+CD28+ T cells (0.4% ± 0.3% perforin+ cells, P = 0.009).
Regulation (negligible) of Gene_expression (expression) of perforin in T cells
1) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.36 Pain Relevance 0.24
LPS-mediated perforin production of CD4+CD28null T cells depends on CD14 and TLR4
Regulation (-) of Gene_expression (production) of perforin in T cells
2) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.69 Pain Relevance 0.42

General Comments

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