INT188585

Context Info Confidence 0.04 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.06 Pain Relevance 0.67

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1) plasma membrane (PRF1)

Anatomy Link Frequency T cells 4 PRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 40 81.48 Arthritis 32 81.12 spinal inflammation 62 80.48 cytokine 10 5.00 Inflammation 4 5.00 tolerance 2 5.00 Infliximab 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 40 81.48 Seronegative Spondarthritis 32 81.12 Low Back Pain 62 80.48 Disease 16 53.32 Necrosis 8 5.00 Cancer 8 5.00 INFLAMMATION 4 5.00 Sprains And Strains 2 5.00 Syndrome 2 5.00 Body Weight 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Figure 4a,b, perforin was produced upon LPS stimulation by CD4+CD28null T cells (13 ± 10.7% perforin+ cells), but perforin expression was negligible in CD4+CD28+ T cells (0.4% ± 0.3% perforin+ cells, P = 0.009).

Regulation (negligible) of Gene_expression (expression) of perforin in T cells

1) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.36 Pain Relevance 0.24

LPS-mediated perforin production of CD4+CD28null T cells depends on CD14 and TLR4

Regulation (-) of Gene_expression (production) of perforin in T cells

2) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.69 Pain Relevance 0.42

General Comments

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