INT188586

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.90
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CD28) plasma membrane (CD28)
Anatomy Link Frequency
blood 2
T cells 2
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 99 99.66 Very High Very High Very High
Inflammation 117 99.48 Very High Very High Very High
Arthritis 38 90.32 High High
spinal inflammation 31 83.88 Quite High
tolerance 11 54.64 Quite High
Bioavailability 8 13.32 Low Low
rheumatoid arthritis 33 13.08 Low Low
withdrawal 1 6.16 Low Low
Inflammatory stimuli 10 5.00 Very Low Very Low Very Low
psoriasis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 131 99.48 Very High Very High Very High
Myeloid Leukemia 2 94.20 High High
Chronic Myeloid Leukemia 2 94.00 High High
Disease 45 91.48 High High
Experimental Arthritis 2 90.32 High High
Pressure And Volume Under Development 11 87.80 High High
Arthritis 22 87.24 High High
Low Back Pain 31 83.88 Quite High
Aging 103 73.40 Quite High
Viral Infection 3 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
Negative_regulation (reversed) of Gene_expression (production) of CD28null in T cells
1) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24
The B7/CD28/CTLA-4 pathway
Negative_regulation (The) of Gene_expression (pathway) of B7/CD28
2) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Consistent with enhanced suppression with pro-inflammatory cytokine primed BMMSCs a decrease in levels of CD28 was observed at 72 hr of activation (Figure 2A).
Negative_regulation (decrease) of Gene_expression (levels) of CD28 associated with inflammation and cytokine
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.16 Pain Relevance 0.23
It has been shown that decreased levels of CD28 expression is directly related to a significant elongation of “reaction time”, required by the CD4+ cells stimulated in vitro before they start first mitosis (Witkowski and Bryl 2004).
Negative_regulation (decreased) of Gene_expression (expression) of CD28
4) Confidence 0.21 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.36 Pain Relevance 0
In a human whole blood assay, 24 inhibited the anti-CD3/CD28 antibody-induced IL-2 production with IC50?
Negative_regulation (inhibited) of Gene_expression (antibody) of CD28 in blood
5) Confidence 0.09 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.54 Pain Relevance 0.14
In an ex vivo anti-CD3/CD-28-induced IL-2 production model in mice, orally administered 23 reduced serum IL-2 levels in a dose-dependent manner with ED50?
Negative_regulation (model) of Gene_expression (production) of CD-28-induced
6) Confidence 0.08 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.60 Pain Relevance 0.08

General Comments

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