INT188588

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 9.19
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
T cells 3
macrophage 1
DCs 1
blood 1
lymphocytes 1
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 339 100.00 Very High Very High Very High
substance P 168 100.00 Very High Very High Very High
cytokine 324 99.68 Very High Very High Very High
rheumatoid arthritis 106 99.52 Very High Very High Very High
chemokine 100 99.12 Very High Very High Very High
qutenza 20 96.20 Very High Very High Very High
Calcitonin gene-related peptide 60 93.60 High High
Crohn's disease 25 93.32 High High
Somatostatin 68 93.12 High High
tolerance 18 91.20 High High
Disease Link Frequency Relevance Heat
Disease 159 100.00 Very High Very High Very High
Inflammatory Bowel Disease 20 100.00 Very High Very High Very High
Cancer 577 99.76 Very High Very High Very High
Synovitis 24 99.72 Very High Very High Very High
Rheumatoid Arthritis 107 99.52 Very High Very High Very High
Asthma 4 99.28 Very High Very High Very High
Atherosclerosis 35 98.40 Very High Very High Very High
Pressure Volume 2 Under Development 8 98.00 Very High Very High Very High
Eye Disease 11 95.36 Very High Very High Very High
Alzheimer's Dementia 71 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DCs did not spontaneously secrete IL-12p70 and IL-10 when cultured in the absence of exogenous stimuli.
Neg (not) Localization (secrete) of DCs
1) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.39 Pain Relevance 0.03
Sparse-scan HIFU was more effective than dense-scan HIFU in enhancing infiltration of DCs into tumor tissues and promoting their maturation in situ
Localization (infiltration) of DCs associated with cancer
2) Confidence 0.46 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 1.00 Pain Relevance 0
Immigrant, tissue-derived DCs were described to localize preferentially in the vicinity of HEVs, where they formed clusters with antigen-specific T cells [39].
Localization (localize) of DCs in T cells
3) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
After 2 days recipient mice were sacrificed, draining popliteal lymph nodes were recovered and analyzed for presence of CFSE+DCs by FACS.


Spec (analyzed) Localization (presence) of DCs in popliteal lymph nodes
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0 Pain Relevance 0
In our investigation of the afferent arm of the immune loop, we observed an accumulation of DCs in the limbus and mobilization of activated DCs into the cornea.
Localization (mobilization) of DCs in cornea
5) Confidence 0.26 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.56 Pain Relevance 0.15
Splenocytes were obtained, stained and analyzed by FACS to evaluate lymphoid DCs (CD11c+ CD8?
Localization (evaluate) of DCs
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
molecules and are thus defined as double negative DCs (CD11b?
Neg (negative) Localization (double) of DCs
7) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0.05
Alternatively, cells activated in the lung by asbestos [e.g., macrophages, dendritic cells (DCs), neutrophils, lymphocytes] may migrate to pulmonary lymph nodes, where they activate CD4+ T cells that are released into the circulation and contribute to atherogenesis.
Localization (released) of DCs in lung associated with atherosclerosis
8) Confidence 0.20 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.78 Pain Relevance 0.12
Strikingly, treatment of microglia with a combination of granulocyte macrophage-colony stimulating factor and CD40L has been shown to promote differentiation of these cells into cells that (1) express the pan-DC marker CD11c, (2) morphologically resemble DCs, and (3) secrete the Th1-promoting cytokine IL-12 p70 [58].
Localization (secrete) of DCs in macrophage associated with cytokine
9) Confidence 0.19 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.71 Pain Relevance 0.20
DCs then up-regulate cell-surface co-stimulatory molecules and secrete innate cytokines and chemokines (typically at levels an order of magnitude higher than those secreted by M?
Localization (secrete) of DCs associated with chemokine and cytokine
10) Confidence 0.19 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.42 Pain Relevance 0.32
From a number of experiments, direct autocrine and/or paracrine effects of endogenously released SP on the immunostimulatory capacity of DCs seem less likely, although it has been shown that SP induces activation of the transcription factor nuclear factor-?
Localization (released) of DCs associated with substance p
11) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.13 Pain Relevance 0.44
It is currently unclear how DCs regulate the release and activity of SP during interaction with T cells, but one interesting study demonstrated the presence of aminopeptidase N on the surface of bronchial mucosal L25+ DCs in patients with asthma.
Localization (presence) of DCs in T cells associated with asthma and substance p
12) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.28 Pain Relevance 0.85
One way in which SP might enhance T cell responses is by recruiting DCs into sites of damage, when it is released very rapidly from nerve endings.
Localization (recruiting) of DCs in nerve associated with substance p
13) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.20 Pain Relevance 0.43
By signalling through the VPAC1 receptor, VIP was shown to induce the maturation of immature DCs leading to an enhanced production of IL-12 and an enhanced expression of the DC-maturation marker CD83, especially in the presence of suboptimal amounts of tumour necrosis factor-?
Localization (maturation) of DCs associated with necrosis and cancer
14) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.40 Pain Relevance 0.17
chemoattractant; DCs, dendritic cells; IBD, inflammatory bowel disease; JD, Johne's disease; LP, lamina propria; MLN, mesenteric lymph nodes; pDCs, plasmacytoid dendritic cells; PP, Peyer's patches; SAA, serum amyloid A; TLR, toll-like receptor; UC, ulcerative colitis.


Localization (disease) of DCs in lamina associated with inflammatory bowel disease, inflammation, alzheimer's dementia and disease
15) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.33 Pain Relevance 0.17
In RA synovitis, both mature DCs (defined as CD1a-positive cells) and immature DCs (defined as DC-LAMP [lysosomal-associated membrane protein]-positive cells) are localized in perivascular infiltrates [4].
Localization (localized) of DCs associated with synovitis and rheumatoid arthritis
16) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.56 Pain Relevance 0.47
In RA synovitis, both mature DCs (defined as CD1a-positive cells) and immature DCs (defined as DC-LAMP [lysosomal-associated membrane protein]-positive cells) are localized in perivascular infiltrates [4].
Localization (localized) of DCs associated with synovitis and rheumatoid arthritis
17) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.55 Pain Relevance 0.47
This suggests that prolonged attempts at definitive surgery were abandoned and the concepts of abbreviated operation and DCS were adopted relatively quickly once significant blood loss (on average 2l) was encountered.
Localization (operation) of DCS in blood associated with pressure volume 2 under development
18) Confidence 0.06 Published 2010 Journal Journal of Emergencies, Trauma and Shock Section Body Doc Link PMC2884440 Disease Relevance 0.36 Pain Relevance 0
Following antigenic stimulation both DCs and T-cells upregulate C3a and C5a receptors, produce C3, alternative complement factors B and D, and downregulate CD55.
Localization (stimulation) of DCs in T-cells
19) Confidence 0.05 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.54 Pain Relevance 0.11
GM-CSF engenders protective immunity by stimulating the recruitment, maturation, and function of DCs, while IL-12 released from DCs directly primes effector lymphocytes at local environments.
Localization (released) of DCs in lymphocytes
20) Confidence 0.05 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.77 Pain Relevance 0.11

General Comments

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