INT188590

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 16.56
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
bone marrow 6
DCs 4
T cell 4
spleen 3
B cell 2
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 52 99.92 Very High Very High Very High
Arthritis 213 98.80 Very High Very High Very High
chemokine 82 98.20 Very High Very High Very High
Deep tissue 7 97.98 Very High Very High Very High
cytokine 324 95.88 Very High Very High Very High
aspirin 41 91.84 High High
Inflammation 365 90.84 High High
rheumatoid arthritis 196 77.88 Quite High
Inflammatory response 44 65.32 Quite High
antagonist 16 65.32 Quite High
Disease Link Frequency Relevance Heat
Infection 420 100.00 Very High Very High Very High
Colitis 145 100.00 Very High Very High Very High
Targeted Disruption 21 99.76 Very High Very High Very High
Sepsis 64 99.36 Very High Very High Very High
Apoptosis 48 99.12 Very High Very High Very High
Arthritis 169 98.80 Very High Very High Very High
Coronavirus Infection 112 98.04 Very High Very High Very High
Autoimmune Disease 77 98.04 Very High Very High Very High
Severe Acute Respiratory Syndrome 158 97.88 Very High Very High Very High
Experimental Arthritis 60 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (activate) of Gene_expression (transfer) of DCs associated with agonist
1) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.68 Pain Relevance 0.10
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (transfer) of Gene_expression (transfer) of DCs associated with agonist
2) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.62 Pain Relevance 0.09
Indeed, histological slices from the adductor muscle confirm that the superficial tissue in the occluded limb is more vascularized than the deep tissue after 28 days, again providing evidence of the origin of higher perfusion ratios of LDF compared to DCS.

3.4 Metabolic recovery of the tissue

Positive_regulation (recovery) of Gene_expression (recovery) of DCS in limb associated with deep tissue
3) Confidence 0.30 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0 Pain Relevance 0.05
DCs in the B cell zone moved the fastest (about 4 ?
Positive_regulation (moved) of Gene_expression (moved) of DCs in B cell
4) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.13
2 in bone marrow derived DCs.
Positive_regulation (derived) of Gene_expression (derived) of DCs in bone marrow
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.13 Pain Relevance 0.15
At Day 6 of culture, bone marrow-derived DCs from DBA/1 LacJ mice were transfected with CD40 siRNA or control siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of DCs in bone marrow
6) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0 Pain Relevance 0
DCs were generated from bone marrow progenitors by standard IL-4 and GM-CSF culture and transfected on Day 6 with CD40-siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of DCs in bone marrow
7) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.28 Pain Relevance 0.08
To test this hypothesis, we used CD40-silenced DCs as allostimulators in MLR.
Positive_regulation (used) of Gene_expression (used) of DCs
8) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.26 Pain Relevance 0.06
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (transfer) of Gene_expression (transfer) of rDCs associated with agonist
9) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.66 Pain Relevance 0.09
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (activate) of Gene_expression (transfer) of rDCs associated with agonist
10) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.68 Pain Relevance 0.10
This challenging approach has been tried for the control of allograft rejection in transplantation where Fas ligand-transduced DCs prolonged cardiac allograft survival in mice.49
Positive_regulation (transduced) of Gene_expression (survival) of DCs in DCs
11) Confidence 0.17 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.88 Pain Relevance 0.24
Regarding the mechanism of DC action, adoptive transfer of IL-4-expressing DCs lead to suppression of Th1-type immune responses in the lymph nodes and spleen and diminished the associated humoral immune responses.
Positive_regulation (transfer) of Gene_expression (transfer) of DCs in spleen
12) Confidence 0.17 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 1.10 Pain Relevance 0.22
In a first step, we asked whether uptake of SpFr, complexed or not with 667, could be followed by productive infection of DCs.
Positive_regulation (infection) of Gene_expression (infection) of DCs associated with infection
13) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.43 Pain Relevance 0
As a significant fraction of DCs can express retroviral proteins in mice infected with MuLVs [37], we also considered that cellular ICs may have favored DC-, or DC precursor, infection by FrCasE and, hence, led to the generation of DCs with altered properties possibly influencing CTL responses in infected/treated mice.
Spec (possibly) Positive_regulation (led) of Gene_expression (generation) of DCs associated with infection
14) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.37 Pain Relevance 0
Thus, rather than enhancing the number of DCs expressing viral Env in vivo, the treatment by 667 diminishes it, presumably because reduced viral spread in infected/treated mice limits infection of DC precursors.
Positive_regulation (enhancing) of Gene_expression (expressing) of DCs associated with infection
15) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.52 Pain Relevance 0
s, as DCs are able to directly activate naïve T cells whereas M?
Positive_regulation (activate) of Gene_expression (able) of DCs in T cells
16) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.03
The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge.
Positive_regulation (increased) of Gene_expression (subsets) of DCs associated with colitis
17) Confidence 0.12 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.62 Pain Relevance 0.06
Recent studies have shown that the conversion of DCs to tolerogenic DCs could lead to the inhibition of NF?
Positive_regulation (conversion) of Gene_expression (conversion) of DCs
18) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.82 Pain Relevance 0.16
Recent studies have shown that the conversion of DCs to tolerogenic DCs could lead to the inhibition of NF?
Positive_regulation (conversion) of Gene_expression (conversion) of DCs
19) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.87 Pain Relevance 0.16
The close association between CCL20-producing cells and immature CD1a+ DCs, identified using immunohistochemistry, suggests a link between the accumulation of immature DCs and local production of CCL20.
Positive_regulation (accumulation) of Gene_expression (production) of DCs
20) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.54 Pain Relevance 0.51

General Comments

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