INT188591

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.90
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
macrophages 4
ridge 2
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 28 99.62 Very High Very High Very High
antagonist 25 98.92 Very High Very High Very High
Inflammation 48 95.20 Very High Very High Very High
substance P 11 45.52 Quite Low
agonist 1 35.44 Quite Low
chemokine 10 26.96 Quite Low
imagery 36 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 49 95.20 Very High Very High Very High
Pulmonary Disease 26 87.32 High High
Airway Obstruction 1 84.36 Quite High
Nicotine Addiction 9 83.28 Quite High
Septic Shock 22 63.08 Quite High
Endotoxemia 15 51.24 Quite High
Injury 8 39.76 Quite Low
Pneumonia 7 10.92 Low Low
Apoptosis 19 5.00 Very Low Very Low Very Low
Sepsis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar high concentration of interacting T cells and DCs was observed in the interfollicular region ('cortical ridge').
Positive_regulation (concentration) of DCs Binding (interacting) of in ridge
1) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
Importantly, we confirmed the in vivo role of the NK1 receptor in CS-induced recruitment of macrophages and DCs by using the NK1 receptor antagonist RP 67580.
Positive_regulation (induced) of DCs Binding (recruitment) of in macrophages associated with antagonist
2) Confidence 0.16 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.47 Pain Relevance 0.13
As such, we investigated whether PAF could directly suppress cytokines production in LPS-stimulated macrophages and DCs.
Positive_regulation (stimulated) of DCs Binding (macrophages) of in macrophages associated with cytokine
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.43 Pain Relevance 0.56

General Comments

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