INT188633

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Sig (Mus musculus)
Pain Link Frequency Relevance Heat
cva 18 37.20 Quite Low
alcohol 15 5.00 Very Low Very Low Very Low
iatrogenic 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acid Base Imbalance 204 100.00 Very High Very High Very High
Disease 3 100.00 Very High Very High Very High
Acidosis 93 99.92 Very High Very High Very High
Hepatotoxicity 3 98.72 Very High Very High Very High
Hypoxia 18 97.60 Very High Very High Very High
Hemorrhagic Shock 51 92.56 High High
Malaria 9 92.00 High High
Critical Illness 84 89.36 High High
Vasculitis 9 85.12 High High
Injury 15 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that a pattern is emerging in which studies conducted in different countries have shown different baseline levels of SIG and have noted differences in their clinical significance [15,20,23,24,40].
Gene_expression (levels) of SIG
1) Confidence 0.36 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.57 Pain Relevance 0
The authors found that even in fatal cases of this disease state, the predominant form of metabolic acidosis was not lactate but rather unaccounted anion, or SIG, acidosis.
Gene_expression (found) of SIG associated with acidosis, disease and acid base imbalance
2) Confidence 0.35 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.97 Pain Relevance 0
Mean lactate levels were surprisingly low in both survivors (2.7 mEq/l) and nonsurvivors (4.0 mEq/l), whereas SIG levels were elevated in both (9.7 mEq/l and 15.9 mEq/l, respectively).
Gene_expression (levels) of SIG
3) Confidence 0.35 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.82 Pain Relevance 0
The data from the present study strongly suggest that large amounts of unmeasured anions, expressed either as the AG or as the SIG, are likely to be generated during states of global tissue hypoxia.
Gene_expression (expressed) of SIG associated with hypoxia
4) Confidence 0.23 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.39 Pain Relevance 0
This is not entirely unexpected since the generation of the SIG is most probably multifactorial.
Gene_expression (generation) of SIG
5) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.45 Pain Relevance 0
It is now becoming apparent that different forms of acidosis and even different types of metabolic acidosis produce different effects [38], and SIG generation may be one feature.
Gene_expression (generation) of SIG associated with acidosis and acid base imbalance
6) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.68 Pain Relevance 0

General Comments

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