INT188634

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 14
Disease Relevance 8.76
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
superior 2
liver 1
Sig (Mus musculus)
Pain Link Frequency Relevance Heat
cva 54 76.64 Quite High
ischemia 9 47.00 Quite Low
alcohol 45 5.00 Very Low Very Low Very Low
iatrogenic 20 5.00 Very Low Very Low Very Low
anesthesia 18 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
Catecholamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 9 99.18 Very High Very High Very High
Shock 388 99.16 Very High Very High Very High
Vasculitis 23 99.04 Very High Very High Very High
Acid Base Imbalance 384 98.76 Very High Very High Very High
Injury 29 98.52 Very High Very High Very High
Congenital Anomalies 58 98.36 Very High Very High Very High
Acidosis 179 97.62 Very High Very High Very High
Hypoxia 50 96.84 Very High Very High Very High
Hemorrhagic Shock 153 91.80 High High
Disease 5 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, these high levels of SIG may be seen in the absence of acid–base abnormalities using traditional acid–base measurements (e.g.
Positive_regulation (levels) of SIG associated with congenital anomalies
1) Confidence 0.41 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.24 Pain Relevance 0
Some causes may be obvious with a single contributing anion, such as a pure lactate acidosis, whereas other complex disorders may not have a single and identifiable, causative anion and only the strong ion gap (SIG) is elevated.
Positive_regulation (elevated) of SIG associated with acidosis
2) Confidence 0.36 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 1.45 Pain Relevance 0
This important study supports the hypothesis that SIG may be a rapidly accumulating biomarker that reflects severity of injury or illness, similar to other acute phase proteins.
Positive_regulation (accumulating) of SIG associated with injury
3) Confidence 0.30 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.95 Pain Relevance 0
Also, in a study investigating the cause of the metabolic acidosis after cardiac arrest, Makino and colleagues [29] showed that increases in SIG contributed approximately 33% to the metabolic acidosis.
Positive_regulation (increases) of SIG associated with myocardial infarction and acid base imbalance
4) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.61 Pain Relevance 0
An increased SIG appears to occur in patients with renal [30] and hepatic [7] impairment, and unexplained anions have been shown experimentally to arise from the liver in animals challenged with bolus intravenous endotoxin [31].
Positive_regulation (increased) of SIG in liver
5) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.66 Pain Relevance 0
Also, in patients with major vascular injury [28] and in children following cardiopulmonary bypass surgery [27,37], an elevated SIG appeared to be superior to other conventional mortality predictors.
Positive_regulation (elevated) of SIG in superior associated with vasculitis
6) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.67 Pain Relevance 0
This finding is in line with results of Kaplan and Kellum [28], who reported increases in SIG in patients with major vascular injury, a condition generally associated with global tissue hypoperfusion.
Positive_regulation (increases) of SIG associated with vasculitis
7) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.45 Pain Relevance 0
These increases in AG and SIG were only temporary and both returned to near-baseline values after completion of resuscitation.
Positive_regulation (increases) of SIG
8) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.46 Pain Relevance 0.04
Major limitations in the interpretation of current literature evaluating outcomes can be condensed into three areas: varying results based on technologic differences between flame photometry, indirect ISEs, and direct ISEs; lack of consistent nomenclature classifying subgroups of metabolic acidosis; and confounding of results by administration of medications or fluids used for resuscitation that will exogenously elevate the SIG (e.g. gelatins).
Positive_regulation (elevate) of SIG associated with acid base imbalance
9) Confidence 0.24 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.53 Pain Relevance 0
Mean lactate levels were surprisingly low in both survivors (2.7 mEq/l) and nonsurvivors (4.0 mEq/l), whereas SIG levels were elevated in both (9.7 mEq/l and 15.9 mEq/l, respectively).
Positive_regulation (elevated) of SIG
10) Confidence 0.24 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 0.82 Pain Relevance 0
Gelatins have been shown to increase both AG and SIG, most likely due to their negative charge and relatively long circulating half-life [40].
Positive_regulation (increase) of SIG
11) Confidence 0.18 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.54 Pain Relevance 0
The difference between SIDa and SIDe has been termed SIG and attains a positive value when unmeasured anions are present in excess of unmeasured cations and attains a negative value when unmeasured cations exceed unmeasured anions [7].
Positive_regulation (termed) of SIG
12) Confidence 0.18 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.27 Pain Relevance 0
Also, in patients with major vascular injury [28] and in children following cardiopulmonary bypass surgery [27,37], an elevated SIG appeared to be superior to other conventional mortality predictors.
Positive_regulation (elevated) of SIG in superior associated with vasculitis
13) Confidence 0.18 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.67 Pain Relevance 0
The increases in citrate (-2.2 mEq/L), acetate (-2.2 mEq/L), and sulfate (-0.1 mEq/L) concentration together accounted for approximately 63% (-4.5 mEq/L) of the increase in SIG during induction of shock.
Positive_regulation (increase) of SIG associated with shock
14) Confidence 0.16 Published 2007 Journal Crit Care Section Body Doc Link PMC2246228 Disease Relevance 0.46 Pain Relevance 0

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