INT188672

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 13.10
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) signal transduction (Tlr9) endoplasmic reticulum (Tlr9)
plasma membrane (Tlr9) intracellular (Tlr9) lysosome (Tlr9)
Anatomy Link Frequency
macrophages 1
hepatocyte 1
liver 1
microglia 1
PDCs 1
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 271 99.70 Very High Very High Very High
Paracetamol 8 99.40 Very High Very High Very High
Morphine 120 99.12 Very High Very High Very High
Inflammation 318 94.40 High High
ischemia 14 92.36 High High
Hippocampus 3 90.48 High High
antagonist 9 89.92 High High
aspirin 1 88.64 High High
agonist 35 87.60 High High
Opioid 36 86.64 High High
Disease Link Frequency Relevance Heat
Apoptosis 187 99.98 Very High Very High Very High
Mycobacterial Infection 237 99.52 Very High Very High Very High
Disease 215 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 60 99.32 Very High Very High Very High
Autoimmune Disease 128 99.24 Very High Very High Very High
Infection 301 99.16 Very High Very High Very High
Targeted Disruption 66 99.12 Very High Very High Very High
Death 44 98.92 Very High Very High Very High
Injury 84 98.28 Very High Very High Very High
Viral Infection 21 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, morphine and H37Ra-indcued increase in CFU count was significantly inhibited in the lung tissues from the TLR9 KO mice, suggesting that this additive effect requires TLR9.
Positive_regulation (requires) of TLR9 in lung associated with targeted disruption and morphine
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.92 Pain Relevance 0.99
Therefore, morphine and M. tuberculosis-induced cell apoptosis requires TLR9.
Positive_regulation (requires) of TLR9 associated with mycobacterial infection, apoptosis and morphine
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.91 Pain Relevance 1.15
Activation of cultured microglia with toll-like receptor 2 (TLR2), TLR4, or TLR9 ligand markedly boosted ingestion of A?
Positive_regulation (Activation) of TLR9 in microglia
3) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.28 Pain Relevance 0.15
PDCs in SLE patients appear to be constantly activated through TLR9 by self-chromatin-antichromatin antibody complexes to produce type I IFNs [34].
Positive_regulation (activated) of TLR9 associated with systemic lupus erythematosus
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.20 Pain Relevance 0
Finally, in the context of TLR9 activation it has been shown that macrophages and neutrophils infiltrate the placental zone and lead to preterm birth or intrauterine fetal death outcomes.
Positive_regulation (activation) of TLR9 in neutrophils associated with premature birth and fetal death
5) Confidence 0.29 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.91 Pain Relevance 0.14
Similarly, stimulation of TLR9 via DNA containing unmethylated CpG motifs results in IFN-?
Positive_regulation (stimulation) of TLR9
6) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.09
In acetaminophen injury, acetaminophen treatment results in hepatocyte death and the free DNA released from apoptotic hepatocytes activates TLR9.
Positive_regulation (activates) of TLR9 in hepatocyte associated with paracetamol, injury, apoptosis and death
7) Confidence 0.26 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.63 Pain Relevance 0.71
Furthermore, DNA released from necrotic hepatocytes stimulates cytokine synthesis via activation of TLR9 during murine acetaminophen-induced liver injury [122].
Positive_regulation (activation) of TLR9 in liver associated with paracetamol, injury and cytokine
8) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.20 Pain Relevance 0.39
Experimental analysis of sequential activation of TLR7, 8 and 9 in HEK293 cells demonstrated that activation of TLR9 inhibited TLR7 activation but not vice versa [207].
Positive_regulation (activation) of TLR9
9) Confidence 0.24 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.64 Pain Relevance 0.19
Activation of the CpG ODN/TLR9 signalling pathway culminates in the activation of several transcription factors [10, 88, 89] which directly up-regulate production of pro-inflammatory cytokines (IL-1, -6, -10, -12 -18, GM-CSF, TNF-?
Positive_regulation (Activation) of TLR9 associated with inflammation and cytokine
10) Confidence 0.24 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.36 Pain Relevance 0.20
Similarly, HMGB1 mediates the activation of plasmacytoid DCs and B cells through TLR9 by DNA-containing immune complexes through a mechanism involving the immunoglobulin superfamily member RAGE [46].
Positive_regulation (activation) of TLR9 in B cells
11) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.16 Pain Relevance 0.03
It has been suggested that TLR9 activation triggers systemic autoimmunity and contributes through adaptive and innate immune mechanisms to the CpG-DNA-induced succession of lupus nephritis [67].
Positive_regulation (activation) of TLR9 associated with autoimmune disease and renal disease
12) Confidence 0.19 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.55 Pain Relevance 0.08
Activation of naïve polyclonal B cell proliferation by TLR7 ligands such as resiquimod (R848) and loxoribine requires the presence of plasmacytoid dendritic cells (PDCs), whereas similar activation via the TLR9 ligand CpG is independent of PDCs.
Positive_regulation (activation) of TLR9 in PDCs
13) Confidence 0.19 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.69 Pain Relevance 0.10
Amongst the TLR genes, we found that mRNA transcripts for TLR 1, 2, 12 and 13, were significantly induced at day 21 (Table 2), while induction of TLR4 or TLR9 was not detected on D21 post infection.
Positive_regulation (induction) of TLR9 associated with infection
14) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.75 Pain Relevance 0.12
Finally, in the context of TLR9 activation it has been shown that macrophages and neutrophils infiltrate the placental zone and lead to preterm birth or intrauterine fetal death outcomes.
Positive_regulation (activation) of TLR9 in macrophages associated with premature birth and fetal death
15) Confidence 0.10 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.91 Pain Relevance 0.14

General Comments

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