INT188675

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 0.98
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf3) DNA binding (Irf3) cytoplasm (Irf3)
Irf3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 145 94.56 High High
Paracetamol 366 89.96 High High
Inflammation 136 77.12 Quite High
depression 14 70.08 Quite High
rheumatoid arthritis 135 58.08 Quite High
Multiple sclerosis 15 38.96 Quite Low
metalloproteinase 16 37.68 Quite Low
Central nervous system 21 32.80 Quite Low
tolerance 2 25.28 Quite Low
Arthritis 30 6.04 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 157 77.12 Quite High
Depression 12 70.08 Quite High
Myocardial Infarction 54 69.36 Quite High
Cancer 20 61.68 Quite High
Necrosis 19 61.12 Quite High
Rheumatoid Arthritis 135 58.08 Quite High
Infection 14 56.44 Quite High
Demyelinating Disease 20 53.76 Quite High
Encephalitis 4 49.36 Quite Low
Multiple Sclerosis 16 45.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zbp1 activation of IRF3 is dependent on the recruitment of TBK-1 (TANK-binding kinase-1) and an I?
Positive_regulation (activation) of IRF3
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.14
Zbp1 is a cytosolic “danger” sensor that activates IRF3 and NF-?
Positive_regulation (activates) of IRF3
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.06 Pain Relevance 0.19
Ifit-3 is involved in the activation of cytosolic IRF-3 and NF-?
Positive_regulation (activation) of IRF-3
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.68
TLR4 can activate TRIF-dependent pathways without MyD88 association, leading to activation of the transcription factor IRF3, in turn producing interferon and costimulatory molecules.


Positive_regulation (activation) of IRF3
4) Confidence 0.36 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.12 Pain Relevance 0.06
B) or independent of MyD88, leading to activation of interferon regulatory factor (IRF3).
Positive_regulation (activation) of IRF3
5) Confidence 0.24 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.12 Pain Relevance 0
TRIF interaction with TBK1 is necessary for the activation of IRF3, which is a transcription factor involved in the production of IFN-?
Positive_regulation (activation) of IRF3
6) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.18 Pain Relevance 0.10
These adapter molecules bind to the intracellular leucine-rich repeat region of the TLR and promote recruitment of additional factors such as IRAKs and TRAF6 that allow for activation of transcription factors including IRF-3 and NF-?
Positive_regulation (activation) of IRF-3
7) Confidence 0.18 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.19 Pain Relevance 0.15
The dissociation of TRIF activates a complex consisting of the kinases IkappaB kinase (IKK)i and TANK-binding kinase (TBK)-1 as well as the scaffolding protein TRAF3 [58], which ultimately leads to the activation of IRF-3 and IRF-7 and the expression of IFN-inducible genes such as those encoding IFN-?
Positive_regulation (activation) of IRF-3
8) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.17 Pain Relevance 0.06
, initially induced through IRF-3, is responsible for NF-?
Positive_regulation (induced) of IRF-3
9) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0 Pain Relevance 0

General Comments

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