INT188677

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) signal transduction (Tlr9) endoplasmic reticulum (Tlr9)
plasma membrane (Tlr9) intracellular (Tlr9) lysosome (Tlr9)
Anatomy Link Frequency
liver 2
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 46 100.00 Very High Very High Very High
Paracetamol 1 99.40 Very High Very High Very High
Inflammation 96 90.24 High High
rheumatoid arthritis 7 57.68 Quite High
chemokine 6 53.80 Quite High
Multiple sclerosis 8 47.84 Quite Low
Osteoarthritis 1 22.32 Low Low
Central nervous system 18 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 21 98.28 Very High Very High Very High
Sepsis 10 94.16 High High
Arthritis 6 90.24 High High
INFLAMMATION 97 85.08 High High
Disease 43 81.84 Quite High
Cancer 4 65.64 Quite High
Rheumatoid Arthritis 7 57.68 Quite High
Demyelinating Disease 13 47.84 Quite Low
Pulmonary Disease 1 39.56 Quite Low
Systemic Lupus Erythematosus 6 30.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, stimulation of TLR9 via DNA containing unmethylated CpG motifs results in IFN-?
Positive_regulation (results) of Positive_regulation (stimulation) of TLR9
1) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.09
Furthermore, DNA released from necrotic hepatocytes stimulates cytokine synthesis via activation of TLR9 during murine acetaminophen-induced liver injury [122].
Positive_regulation (stimulates) of Positive_regulation (activation) of TLR9 in liver associated with paracetamol, injury and cytokine
2) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.22 Pain Relevance 0.40

General Comments

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