INT188678

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.60
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Anatomy Link Frequency
B-cell 2
intermediary 1
plasma cells 1
neutrophils 1
kidney 1
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 95 99.96 Very High Very High Very High
Inflammation 197 99.80 Very High Very High Very High
cytokine 316 99.28 Very High Very High Very High
cINOD 5 83.80 Quite High
corticosteroid 3 82.12 Quite High
rheumatoid arthritis 23 63.92 Quite High
Inflammatory response 24 63.44 Quite High
chemokine 26 61.88 Quite High
Central nervous system 51 53.28 Quite High
tolerance 36 52.88 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 557 100.00 Very High Very High Very High
INFLAMMATION 216 99.80 Very High Very High Very High
Vesicular Stomatitis 6 99.38 Very High Very High Very High
Hypersensitivity 17 98.08 Very High Very High Very High
Disease 224 97.76 Very High Very High Very High
Systemic Lupus Erythematosus 305 97.20 Very High Very High Very High
Targeted Disruption 27 92.24 High High
Skin Cancer 9 89.04 High High
Renal Disease 39 87.88 High High
Infection 293 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As CHIKV is an ssRNA virus and likely replicates with a dsRNA intermediary, we predicted engagement of TLR7 and/or TLR3.
TLR7 Binding (engagement) of in intermediary
1) Confidence 0.32 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2822618 Disease Relevance 0.51 Pain Relevance 0.07
This induction of autophagy appears to be effective in eliminating intracellular microbes, even when the target pathogen is normally not associated with TLR7 signalling [166].
TLR7 Binding (associated) of
2) Confidence 0.27 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.55 Pain Relevance 0.26
Unmethylated CpG dinucleotides present in bacterial DNA are recognized by TLR9 [11–13], single-stranded (ss)RNA viruses, such as vesicular stomatitis virus and influenza virus are recognized by TLR7 [14], and dsRNA longer than 30 base pairs, produced during the viral replicative cycle, is recognized by TLR3 [11, 13, 15, 16].
TLR7 Binding (recognized) of associated with influenza virus infection and vesicular stomatitis
3) Confidence 0.23 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.63 Pain Relevance 0.04
TLR7 is essential for influenza viral recognition and inflammatory cytokine production by murine neutrophils [159, 167].
TLR7 Binding (recognition) of in neutrophils associated with inflammation, influenza virus infection and cytokine
4) Confidence 0.21 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.58 Pain Relevance 0.27
TLR7 is an intracellular TLR, located on endosomal membranes, which recognizes ssRNA in a sequence-independent manner as long as the RNA contains several uridine residues in close proximity to each other [158, 159].
TLR7 Binding (recognizes) of
5) Confidence 0.20 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.25 Pain Relevance 0.13
Nucleosides and nucleotides from intracellular pathogens, guanine nucleoside analogues, stabilized immunoregulatory RNA, short dsRNA oligonucleotides containing several uridine residues in close proximity (i.e. short interfering RNA (siRNA)) [160] and imidoazoquinoline-based compounds such as 852A and imiquimod (IMQ) [161] are also recognized by TLR7.
TLR7 Binding (recognized) of
6) Confidence 0.20 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.26 Pain Relevance 0.17
In vivo studies in systemic lupus erythematosus (SLE) mouse models demonstrate an essential role for TLR7 in the generation of RNA-containing antinuclear antibodies and deposition of pathogenic immune complexes in the kidney, with TLR7 recognizing RNA- and DNA-containing autoimmune complexes and TLR9 amplifying the autoimmune response [170].
TLR7 Binding (recognizing) of in kidney associated with systemic lupus erythematosus
7) Confidence 0.20 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.76 Pain Relevance 0.25
Single-stranded RNA is recognized by TLR7 and TLR8, and TLR9 recognizes DNA which can be either host or pathogen derived [3].
TLR7 Binding (recognized) of
8) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0 Pain Relevance 0.08
Banchereau and Pascual [26] have demonstrated that ICs are formed when autoantibodies are engaged with either (1) chromatin whose DNA can interact with TLR9 inside pDC and B-cell endosomes or (2) ribonucleoproteins whose RNA can interact with TLR7 also inside pDC and B-cell endosomes.
TLR7 Binding (can inte) of in B-cell
9) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.41 Pain Relevance 0.08
Also, in the presence of type I interferon (IFN), ligation of TLR7 triggers the multiplication of polyclonal B cells and their subsequent differentiation toward Ig-producing plasma cells.
TLR7 Binding (ligation) of in plasma cells
10) Confidence 0.18 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.75 Pain Relevance 0.13
Finally, B cells are activated by DNA- or RNA-associated autoantigens by combined B cell antigen receptor (BCR)/TLR9 or TLR7 engagement [93, 94].
TLR7 Binding (engagement) of in B cell
11) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.16 Pain Relevance 0
Stimulation of human pDCs or monocytic DCs with synthetic TLR7 ligands induces the secretion of interferon (IFN)-?
TLR7 Binding (ligands) of
12) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11
Briefly, TLR2, which works with TLR1 or TLR6, recognizes bacterial components, such as lipopeptide and lipoprotein of gram-positive bacteria; specifically, the heterodimer TLR1/2 which can recognize triacyl lipopeptide, while TLR2/6 recognizes diacyl lipopeptide.TLR7 is documented to recognize RNA, while TLR9-DNA, both microbial and self [89, 90].


TLR7 Binding (recognize) of
13) Confidence 0.10 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.25 Pain Relevance 0.06
The role of nucleic acid binding TLR 7 has become quite apparent in both animal models of the disease and human patients.
TLR 7 Binding (nucleic acid binding) of associated with disease
14) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 1.50 Pain Relevance 0.25

General Comments

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