INT188682

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.75
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd86)
Anatomy Link Frequency
blood 1
immune cells 1
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 57 99.56 Very High Very High Very High
psoriasis 2 88.68 High High
rheumatoid arthritis 8 88.12 High High
tolerance 4 77.92 Quite High
Arthritis 4 74.20 Quite High
Inflammation 66 70.52 Quite High
Inflammatory response 4 59.60 Quite High
chemokine 5 47.80 Quite Low
Central nervous system 18 35.84 Quite Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 99.40 Very High Very High Very High
Necrosis 5 98.90 Very High Very High Very High
Cancer 6 98.88 Very High Very High Very High
Psoriasis 2 88.68 High High
Rheumatoid Arthritis 8 88.12 High High
Graft Vs Host Disease 2 87.00 High High
Autoimmune Disease 19 82.00 Quite High
Colitis 2 79.84 Quite High
Lyme Disease 4 74.20 Quite High
Borrelia Infection 2 71.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examples of these mechanisms include a restrictive blood-ocular barrier, lack of lymphatic drainage networks, absence of molecules involved in antigen presentation, such as major histocompatibility complex (MHC) class II, expression of molecules involved in immunomodulation, such as Fas-FasL, tumor necrosis factor–related apoptosis-inducing ligand (TRAIL), and B7.2, and the presence or secretion of immunoregulatory factors, such as ?
Localization (secretion) of B7.2 in blood associated with necrosis, cancer and apoptosis
1) Confidence 0.68 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.54 Pain Relevance 0.11
These findings revealed the importance of B7.1 and B7.2 as negative regulators of human Th17 development.
Localization (importance) of B7
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 1.01 Pain Relevance 0.22
These findings revealed the importance of B7.1 and B7.2 as negative regulators of human Th17 development.
Localization (importance) of B7
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 1.01 Pain Relevance 0.22
Together with Ruslan Mezhitov, he originated the concept that these phagocytic innate immune cells recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors, the most notable examples being a set of phylogenetically conserved, germ-line encoded Toll-like receptors (TLRs, currently 11–12 members, [7-10]), resulting in expression of cell-surface activation molecules [for example, major histocompatibility complex (MHC) class I and II, B7.1, B7.2, and CD40] and secretion of innate cytokines [i.e., tumor necrosis factor ?
Localization (secretion) of B7.2 in immune cells associated with necrosis, cancer and cytokine
4) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.20 Pain Relevance 0.05

General Comments

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