INT188685

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.61
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf3) DNA binding (Irf3) cytoplasm (Irf3)
Irf3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 73 94.56 High High
Inflammation 82 77.12 Quite High
depression 4 67.52 Quite High
rheumatoid arthritis 70 58.60 Quite High
Paracetamol 122 54.64 Quite High
Multiple sclerosis 8 38.96 Quite Low
metalloproteinase 3 38.20 Quite Low
Central nervous system 19 32.80 Quite Low
Arthritis 15 6.56 Low Low
antagonist 7 5.88 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 90 77.12 Quite High
Depression 4 67.52 Quite High
Necrosis 9 59.88 Quite High
Cancer 10 59.52 Quite High
Rheumatoid Arthritis 70 58.60 Quite High
Infection 6 56.96 Quite High
Demyelinating Disease 13 53.76 Quite High
Encephalitis 4 49.36 Quite Low
Multiple Sclerosis 16 45.84 Quite Low
Disease 47 39.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zbp1 activation of IRF3 is dependent on the recruitment of TBK-1 (TANK-binding kinase-1) and an I?
Positive_regulation (dependent) of Positive_regulation (activation) of IRF3
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.19
TRIF interaction with TBK1 is necessary for the activation of IRF3, which is a transcription factor involved in the production of IFN-?
Positive_regulation (necessary) of Positive_regulation (activation) of IRF3
2) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.18 Pain Relevance 0.10
These adapter molecules bind to the intracellular leucine-rich repeat region of the TLR and promote recruitment of additional factors such as IRAKs and TRAF6 that allow for activation of transcription factors including IRF-3 and NF-?
Positive_regulation (activation) of Positive_regulation (activation) of IRF-3
3) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.19 Pain Relevance 0.15
The dissociation of TRIF activates a complex consisting of the kinases IkappaB kinase (IKK)i and TANK-binding kinase (TBK)-1 as well as the scaffolding protein TRAF3 [58], which ultimately leads to the activation of IRF-3 and IRF-7 and the expression of IFN-inducible genes such as those encoding IFN-?
Positive_regulation (leads) of Positive_regulation (activation) of IRF-3
4) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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