INT188686

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Spg7) mitochondrion (Spg7) cell adhesion (Spg7)
mitochondrion organization (Spg7)
Anatomy Link Frequency
microglia 1
Spg7 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 1 97.00 Very High Very High Very High
Inflammation 78 78.40 Quite High
cytokine 40 76.80 Quite High
Inflammatory response 2 21.24 Low Low
chemokine 11 19.32 Low Low
Central nervous system 18 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 97.00 Very High Very High Very High
Inflammatory Bowel Disease 15 92.88 High High
Colitis 38 88.60 High High
INFLAMMATION 80 78.40 Quite High
Sprains And Strains 35 71.52 Quite High
Injury 7 60.88 Quite High
Infection 2 31.20 Quite Low
Alzheimer's Dementia 33 5.00 Very Low Very Low Very Low
Multiple Sclerosis 16 5.00 Very Low Very Low Very Low
Demyelinating Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 1, both N9 and primary cultured microglia increased phagocytosis after stimulation with each PAMP studied by as much as ~190% over baseline (see PGN treatment of N9 cells, Fig. 1A).
Positive_regulation (see) of PGN in microglia
1) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.13 Pain Relevance 0.10
Recently Watanabe and colleagues proposed that peptidoglycan (PGN)-mediated activation of TLR2 signaling is negatively regulated by MDP-mediated activation of NOD2 signaling [42].
Positive_regulation (activation) of PGN
2) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.68 Pain Relevance 0.11

General Comments

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