INT188691

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.49
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglia 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 23 99.62 Very High Very High Very High
Arthritis 66 98.80 Very High Very High Very High
cytokine 59 98.44 Very High Very High Very High
Inflammation 36 97.40 Very High Very High Very High
rheumatoid arthritis 26 82.72 Quite High
cva 4 80.24 Quite High
Cannabinoid 11 73.56 Quite High
abatacept 2 61.64 Quite High
antagonist 2 61.20 Quite High
Central nervous system 24 60.08 Quite High
Disease Link Frequency Relevance Heat
Disease 60 99.76 Very High Very High Very High
Experimental Arthritis 40 98.80 Very High Very High Very High
INFLAMMATION 37 97.40 Very High Very High Very High
Recurrence 2 92.40 High High
Autoimmune Disease 15 87.92 High High
Rheumatoid Arthritis 26 82.72 Quite High
Cv General 3 Under Development 4 80.24 Quite High
Injury 7 76.52 Quite High
Alzheimer's Dementia 33 64.64 Quite High
Apoptosis 5 62.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This therapy is highly effective in mouse models [4,18], although the overall benefit of interruption of CD40-CD154 association is reduced when Abs is administrated after disease establishment.
Negative_regulation (reduced) of CD40 Binding (association) of associated with disease
1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.23
Suppression of the CD40-CD154 interaction has been shown to actually induce generation of T regulatory (Treg) cells [8].
Negative_regulation (Suppression) of CD40 Binding (interaction) of
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.91 Pain Relevance 0.38
Having established that CD40 ligation attenuates innate (phagocytic) activation of microglia challenged with A?
Negative_regulation (established) of CD40 Binding (ligation) of in microglia
3) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.37 Pain Relevance 0.35
In this study, we have also shown that CB2 agonist JWH-015 similarly inhibits microglial CD40 ligation-induced production of proinflammatory cytokines.
Negative_regulation (inhibits) of CD40 Binding (ligation) of associated with agonist and cytokine
4) Confidence 0.38 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.38 Pain Relevance 0.35

General Comments

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