INT188692

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 22.95
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40, Cd40lg) extracellular region (Cd40, Cd40lg) plasma membrane (Cd40, Cd40lg)
signal transduction (Cd40lg) enzyme binding (Cd40)
Anatomy Link Frequency
T cell 4
microglia 4
neurons 2
plaques 2
bone marrow 2
Cd40 (Mus musculus)
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 22 99.60 Very High Very High Very High
Multiple sclerosis 52 98.96 Very High Very High Very High
Arthritis 271 98.64 Very High Very High Very High
Inflammation 371 97.84 Very High Very High Very High
Central nervous system 192 96.76 Very High Very High Very High
cytokine 399 95.28 Very High Very High Very High
Nerve growth factor 20 93.96 High High
cva 23 92.88 High High
agonist 52 91.32 High High
Inflammatory mediators 8 90.40 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 148 99.96 Very High Very High Very High
Autoimmune Disease 114 99.76 Very High Very High Very High
Alzheimer's Dementia 276 99.24 Very High Very High Very High
Disease 352 99.12 Very High Very High Very High
Demyelinating Disease 78 98.96 Very High Very High Very High
Amyloid Plaque 58 98.74 Very High Very High Very High
Experimental Arthritis 160 98.64 Very High Very High Very High
Encephalitis 38 98.08 Very High Very High Very High
Thrombosis 3 97.60 Very High Very High Very High
Neurodegenerative Disease 64 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of CD40 to CD40L on T-lymphocytes leads to activation of the antigen presenting cells and T-cells, and produces a variety of downstream effects, including both humoral and cellular immune responses [13-15].
CD40 Binding (Binding) of CD40L in T-cells
1) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.32 Pain Relevance 0.03
This therapy is highly effective in mouse models [4,18], although the overall benefit of interruption of CD40-CD154 association is reduced when Abs is administrated after disease establishment.
CD40 Binding (association) of CD154 associated with disease
2) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.22
Suppression of the CD40-CD154 interaction has been shown to actually induce generation of T regulatory (Treg) cells [8].
CD40 Binding (interaction) of CD154
3) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.90 Pain Relevance 0.37
This therapy is highly effective in mouse models [4,18], although the overall benefit of interruption of CD40-CD154 association is reduced when Abs is administrated after disease establishment.
CD40 Binding (association) of CD154 associated with disease
4) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.22
Suppression of the CD40-CD154 interaction has been shown to actually induce generation of T regulatory (Treg) cells [8].
CD40 Binding (interaction) of CD154
5) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.90 Pain Relevance 0.37
The CD40-CD154 interaction is involved in the initiation of CIA.
CD40 Binding (interaction) of CD154 associated with arthritis
6) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.80 Pain Relevance 0.19
In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.
CD40 Binding (interaction) of CD154 in T cell
7) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.07 Pain Relevance 0.49
In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.
CD40 Binding (interaction) of CD154 in T cell
8) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.07 Pain Relevance 0.49
The CD40-CD154 interaction is involved in the initiation of CIA.
CD40 Binding (interaction) of CD154 associated with arthritis
9) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.80 Pain Relevance 0.19
Nearly 10 years ago, activated Th cells that expressed CD40 ligand (CD40L) were found in brains of MS patients, and these cells were found in close apposition to CD40-bearing cells in active demyelinating lesions [54].
CD40 Binding (ligand) of CD40L in brains associated with multiple sclerosis and demyelinating disease
10) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.79 Pain Relevance 0.13
In an effort to further understand the nature of the CD40-CD40L interaction responsible for promotion of EAE, Becher and colleagues used a bone marrow reconstitution system to determine which CD40-expressing cells were responsible for promoting EAE [57].
CD40 Binding (interaction) of CD40L in bone marrow associated with multiple sclerosis
11) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.78 Pain Relevance 0.08
In an effort to further understand the nature of the CD40-CD40L interaction responsible for promotion of EAE, Becher and colleagues used a bone marrow reconstitution system to determine which CD40-expressing cells were responsible for promoting EAE [57].
CD40 Binding (interaction) of CD40L in bone marrow associated with multiple sclerosis
12) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.78 Pain Relevance 0.08
To evaluate whether the CD40-CD40L interaction was pathogenic in EAE, Gerritse and co-workers administered a CD40L neutralizing antibody to SJL mice that were given proteolipid protein with adjuvant to induce EAE.
CD40 Binding (interaction) of CD40L associated with multiple sclerosis
13) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.72 Pain Relevance 0.14
-amyloid plaques in AD patient brain [78,79], raising the possibility that the CD40-CD40L interaction may contribute to AD pathogenesis by promoting brain inflammation.
CD40 Binding (interaction) of CD40L in plaques associated with inflammation, alzheimer's dementia, encephalitis and amyloid plaque
14) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.08 Pain Relevance 0.05
-amyloid plaques in AD patient brain [78,79], raising the possibility that the CD40-CD40L interaction may contribute to AD pathogenesis by promoting brain inflammation.
CD40 Binding (interaction) of CD40L in plaques associated with inflammation, alzheimer's dementia, encephalitis and amyloid plaque
15) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.08 Pain Relevance 0.05
Thus, in the context of EAE, CD40-CD40L interaction on microglia seems to promote adaptive function of these cells, resulting in a "DC-like" activated microglia phenotype that promotes encephalitogenic Th1 cell differentiation and effector function.


CD40 Binding (interaction) of CD40L in microglia associated with multiple sclerosis
16) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.98 Pain Relevance 0.17
Thus, in the context of EAE, CD40-CD40L interaction on microglia seems to promote adaptive function of these cells, resulting in a "DC-like" activated microglia phenotype that promotes encephalitogenic Th1 cell differentiation and effector function.


CD40 Binding (interaction) of CD40L in microglia associated with multiple sclerosis
17) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.98 Pain Relevance 0.17
One of these strategies involves blockade of the binding of CD40 to CD40 ligand (CD40L, also known as CD154).
CD40 Binding (binding) of CD154
18) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.29 Pain Relevance 0.03
Given the recently described immunomodulatory role of cannabinoids, the importance of CD40-CD40L interaction in neuroinflammatory diseases, and the clinical and basic science studies suggesting that cannabinoids may be therapeutic in AD and MS, [21-25], we examined, in the present study, whether cannabinoids (primarily CB2 agonist JWH-015) could oppose microglial CD40 expression following interferon-?
CD40 Binding (interaction) of CD40L associated with multiple sclerosis, cannabinoid, agonist and disease
19) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.85 Pain Relevance 0.42
Given the recently described immunomodulatory role of cannabinoids, the importance of CD40-CD40L interaction in neuroinflammatory diseases, and the clinical and basic science studies suggesting that cannabinoids may be therapeutic in AD and MS, [21-25], we examined, in the present study, whether cannabinoids (primarily CB2 agonist JWH-015) could oppose microglial CD40 expression following interferon-?
CD40 Binding (interaction) of CD40L associated with multiple sclerosis, cannabinoid, agonist and disease
20) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.85 Pain Relevance 0.42

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