INT188698

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hand1, Mthfd1) cell differentiation (Hand1) nucleoplasm (Hand1)
mitochondrion (Mthfd1) enzyme binding (Hand1) DNA binding (Hand1)
Anatomy Link Frequency
macrophage 2
Hand1 (Mus musculus)
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 32 99.96 Very High Very High Very High
Inflammation 29 92.00 High High
Central nervous system 18 74.96 Quite High
Multiple sclerosis 4 33.84 Quite Low
Nerve growth factor 1 23.88 Low Low
chemokine 5 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 16 93.68 High High
INFLAMMATION 28 92.00 High High
Disease 7 60.00 Quite High
Demyelinating Disease 9 37.96 Quite Low
Alzheimer's Dementia 32 30.80 Quite Low
Dementia 1 18.16 Low Low
Cognitive Disorder 2 9.60 Low Low
Amyloid Plaque 7 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Encephalitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strikingly, treatment of microglia with a combination of granulocyte macrophage-colony stimulating factor and CD40L has been shown to promote differentiation of these cells into cells that (1) express the pan-DC marker CD11c, (2) morphologically resemble DCs, and (3) secrete the Th1-promoting cytokine IL-12 p70 [58].
Th1 Positive_regulation (promoting) of Localization (secrete) of DCs in macrophage associated with cytokine
1) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.71 Pain Relevance 0.20

General Comments

This test has worked.

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